Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn’s and Colitis (PREdiCCt) prospective cohort study - Report - MDSpire
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Exploring the Links Between Demographic, Clinical, and Dietary Influences on Inflammatory Bowel Disease Flares: Insights from the PREdiCCt Prospective Cohort Study

  • By

  • Nathan Constantine-Cooke

  • Beatriz Gros

  • Nikolas Plevris

  • Linda J Williams

  • Gareth-Rhys Jones

  • Janet Kyle

  • Nicholas A Kennedy

  • Victor Velasco-Pardo

  • Alexander Rudge

  • Debbie Alexander

  • Carl A Anderson

  • Maiara Brusco de Freitas

  • Lisa M Derr

  • Lauranne AAP Derikx

  • Sian Gilchrist

  • Paul Henderson

  • Graham W Horgan

  • Peter Irving

  • Christopher A Lamb

  • Luke Jostins-Dean

  • James O Lindsay

  • Jonathan MacDonald

  • Craig Mowat

  • Charles Murray

  • Miles Parkes

  • Spyros I Siakavellas

  • Catalina A Vallejos

  • Daniel R Gaya

  • Jonathan M Rhodes

  • Alexandra M Johnstone

  • Christopher J Weir

  • Charlie W Lees

  • August 1, 2026

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Clinical Report: Links Between Dietary Influences and IBD Flares

Overview

This prospective cohort study involving 2,629 patients identifies a significant association between higher total meat intake and increased risk of objective flares in ulcerative colitis (UC).

Background

Understanding the factors that contribute to inflammatory bowel disease (IBD) flares is crucial for effective management. Previous research has primarily focused on cross-sectional data, leaving a gap in prospective evidence regarding habitual diet and flare risk.

Data Highlights

No numerical data was provided in the source material.

Key Findings

  • Higher total meat intake is associated with an increased risk of objective flares in UC.
  • No consistent associations were found for ultraprocessed foods, fibre, or polyunsaturated fatty acid intake.
  • This study is the largest prospective evaluation of habitual diet and flare risk in IBD to date.

Clinical Implications

Incorporating dietary assessments into routine care may help identify modifiable risk factors for IBD flares.

Conclusion

Further research is warranted to explore dietary interventions.

Related Resources & Content

  1. conexiant, Conexiant, 2025 -- Diet-Microbiome Links Drive IBD Inflammation
  2. The New Gastroenterologist, The New Gastroenterologist, 2025 -- Variability in Plant-based Diets and Their Impact on Inflammatory Bowel Disease Risk
  3. Journal of Gastroenterology, Journal of Gastroenterology, 2013 -- The Interplay of Diet, Microbiota, and Genetic Factors in Inflammatory Bowel Disease Development
  4. Journal of Crohn's and Colitis, Journal of Crohn's and Colitis, 2021 -- A pro-inflammatory diet is associated with growth and virulence of Escherichia coli in pediatric Crohn’s disease
  5. EUR Research Information Portal, EUR Research Information Portal, 2025 -- Dietary Management in IBD
  6. Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial - ScienceDirect, ScienceDirect, 2025 -- Whole Food Diet Induces Remission
  7. EUR Research Information Portal
  8. Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial - ScienceDirect
  9. Results of the Eighth Scientific Workshop of ECCO: Prevention and Treatment of Postoperative Recurrence in Patients With Crohn’s Disease Undergoing an Ileocolonic Resection With Ileocolonic Anastomosis | Journal of Crohn's and Colitis | Oxford Academic

Original Source(s)

Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn’s and Colitis (PREdiCCt) prospective cohort study

  • by Nathan Constantine-Cooke, Beatriz Gros, Nikolas Plevris, Linda J Williams, Gareth-Rhys Jones, Janet Kyle, Nicholas A Kennedy, Victor Velasco-Pardo, Alexander Rudge, Debbie Alexander, Carl A Anderson, Maiara Brusco de Freitas, Lisa M Derr, Lauranne AAP Derikx, Sian Gilchrist, Paul Henderson, Graham W Horgan, Peter Irving, Christopher A Lamb, Luke Jostins-Dean, James O Lindsay, Jonathan MacDonald, Craig Mowat, Charles Murray, Miles Parkes, Spyros I Siakavellas, Catalina A Vallejos, Daniel R Gaya, Jonathan M Rhodes, Alexandra M Johnstone, Christopher J Weir, Charlie W Lees

  • August 1, 2026

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