Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn’s and Colitis (PREdiCCt) prospective cohort study - Report - MDSpire
Conexiant’s news site is now MDSpire News. Learn more
Advertisement
Exploring the Links Between Demographic, Clinical, and Dietary Influences on Inflammatory Bowel Disease Flares: Insights from the PREdiCCt Prospective Cohort Study
Clinical Report: Links Between Dietary Influences and IBD Flares
Overview
This prospective cohort study involving 2,629 patients identifies a significant association between higher total meat intake and increased risk of objective flares in ulcerative colitis (UC).
Background
Understanding the factors that contribute to inflammatory bowel disease (IBD) flares is crucial for effective management. Previous research has primarily focused on cross-sectional data, leaving a gap in prospective evidence regarding habitual diet and flare risk.
Data Highlights
The study found that patients with the highest quintile of meat intake had a 2.5-fold increased risk of experiencing objective flares compared to those in the lowest quintile. Additionally, no significant associations were observed between the intake of ultraprocessed foods, fiber, or polyunsaturated fatty acids and flare risk.
Key Findings
Higher total meat intake is associated with an increased risk of objective flares in UC.
No consistent associations were found for ultraprocessed foods, fibre, or polyunsaturated fatty acid intake.
This study is the largest prospective evaluation of habitual diet and flare risk in IBD to date.
Clinical Implications
Incorporating dietary assessments into routine care may help identify modifiable risk factors for IBD flares.
Conclusion
Further research is warranted to explore dietary interventions.
The New Gastroenterologist, The New Gastroenterologist, 2025 -- Variability in Plant-based Diets and Their Impact on Inflammatory Bowel Disease Risk
Journal of Gastroenterology, Journal of Gastroenterology, 2013 -- The Interplay of Diet, Microbiota, and Genetic Factors in Inflammatory Bowel Disease Development
Journal of Crohn's and Colitis, Journal of Crohn's and Colitis, 2021 -- A pro-inflammatory diet is associated with growth and virulence of Escherichia coli in pediatric Crohn’s disease
EUR Research Information Portal, EUR Research Information Portal, 2025 -- Dietary Management in IBD
Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial - ScienceDirect, ScienceDirect, 2025 -- Whole Food Diet Induces Remission
EUR Research Information Portal
Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial - ScienceDirect
Results of the Eighth Scientific Workshop of ECCO: Prevention and Treatment of Postoperative Recurrence in Patients With Crohn’s Disease Undergoing an Ileocolonic Resection With Ileocolonic Anastomosis | Journal of Crohn's and Colitis | Oxford Academic
by Nathan Constantine-Cooke, Beatriz Gros, Nikolas Plevris, Linda J Williams, Gareth-Rhys Jones, Janet Kyle, Nicholas A Kennedy, Victor Velasco-Pardo, Alexander Rudge, Debbie Alexander, Carl A Anderson, Maiara Brusco de Freitas, Lisa M Derr, Lauranne AAP Derikx, Sian Gilchrist, Paul Henderson, Graham W Horgan, Peter Irving, Christopher A Lamb, Luke Jostins-Dean, James O Lindsay, Jonathan MacDonald, Craig Mowat, Charles Murray, Miles Parkes, Spyros I Siakavellas, Catalina A Vallejos, Daniel R Gaya, Jonathan M Rhodes, Alexandra M Johnstone, Christopher J Weir, Charlie W Lees
