Systematic review of animal studies on the use of herbal medicine for attention-deficit/hyperactivity disorder - Report - MDSpire

Systematic review of animal studies on the use of herbal medicine for attention-deficit/hyperactivity disorder

  • By

  • Gia Linh Mac

  • Khoa Nguyen Tran

  • Tien Dat Tran

  • Haifeng Shao

  • Yang Wang

  • Kyung-Hee Park

  • Hyo-Won Jung

  • In-Jun Yang

  • June 18, 2026

  • 0 min

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Clinical Report: Comprehensive Analysis of Herbal Remedies for ADHD

Overview

This systematic review evaluates preclinical studies on herbal remedies for ADHD, highlighting their potential benefits and significant methodological limitations. Key findings indicate improvements in ADHD-like behaviors but a lack of rigorous safety evaluations and diverse animal models.

Background

ADHD is a prevalent neurodevelopmental disorder affecting 8% of children and adolescents globally, often treated with stimulant medications that can have adverse effects. The rising interest in herbal remedies as alternative treatments necessitates a thorough evaluation of existing preclinical research to understand their efficacy and safety.

Data Highlights

No numerical data available in the source material.

Key Findings

  • 25 preclinical studies were analyzed, predominantly using spontaneously hypertensive rats.
  • 88% of studies exclusively used male animals, limiting generalizability.
  • 72% of studies focused on hyperactivity, with less emphasis on inattention and impulsivity.
  • Herbal interventions showed improvements in ADHD-like behaviors and catecholaminergic neurotransmission.
  • 80% of studies did not report safety outcomes, raising concerns about translational relevance.
  • Promising formulations included Long Mu Qing Xin mixture and An Shen Ding Zhi Ling.

Clinical Implications

Healthcare professionals should be aware of the potential benefits of herbal remedies for ADHD while recognizing the limitations of current preclinical research. Future studies should prioritize methodological rigor and diverse animal models to enhance the translational relevance of findings.

Conclusion

While herbal medicines show promise for ADHD treatment, significant gaps in research quality and safety evaluations must be addressed to inform clinical practice effectively.

Related Resources & Content

  1. BMC Psychiatry (Springer), 2025 -- Efficacy of game-based interventions on cognitive performance in children and adolescents with attention-deficit/hyperactivity disorder: a systematic review and meta–analysis
  2. BMC Psychiatry (Springer), 2025 -- Objective evaluation of attention-deficit/hyperactivity disorder medication effects using a load-cell-embedded chair in a simulated classroom
  3. Frontiers in Psychiatry, 2026 -- Noise, air pollution exposure and attention-deficit/hyperactivity disorder: a meta-analysis
  4. BMC Psychiatry (Springer), 2025 -- Brain–behavior relationships in task-based fMRI assessments of executive functions in children and adolescents with and without ADHD: a systematic review and ALE meta-analysis
  5. Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents - PMC, 2024
  6. Results: Treatment of ADHD - ADHD Diagnosis and Treatment in Children and Adolescents - NCBI Bookshelf
  7. Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents - PMC
  8. Results: Treatment of ADHD - ADHD Diagnosis and Treatment in Children and Adolescents - NCBI Bookshelf

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