Study-level factors associated with hematoma after ultrasound-guided vacuum-assisted breast lesion excision: a systematic review and meta-analysis using a T-P-B framework - Report - MDSpire

Study-level factors associated with hematoma after ultrasound-guided vacuum-assisted breast lesion excision: a systematic review and meta-analysis using a T-P-B framework

  • By

  • Yunzhi Shen

  • Xinran Shao

  • Shuai Ma

  • Yihan Sun

  • Jinrui Liu

  • Pingdong Sun

  • Yuxia Jiang

  • Xiang Fei

  • Ying Zhang

  • Yang Gao

  • Dongning Bi

  • Jianchun Cui

  • Xingai Ju

  • Dongxiao Zhang

  • June 19, 2026

  • 0 min

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Clinical Report: Factors Linked to Hematoma Development After VAE

Overview

This systematic review and meta-analysis identified five study-level factors associated with postoperative hematoma following ultrasound-guided vacuum-assisted excision (VAE) of breast lesions. The findings are organized within a framework highlighting tumor-related, position-related, and breast- or peri-procedural management-related factors.

Background

Postoperative hematoma is a common complication following VAE, which is increasingly utilized for therapeutic lesion removal. Understanding the factors that contribute to hematoma formation is crucial. This study aims to consolidate existing evidence and provide a structured framework for risk assessment.

Data Highlights

FactorOdds Ratio (OR)95% Confidence Interval (CI)
Tumor Numbers4.212.59–6.85
Numbers of Cutting Passes3.872.16–6.95
Non-Moderate Tumor Depth4.391.21–15.92
Higher Vascularity Grade2.601.42–4.76
Postoperative Compression Duration < 48 h4.342.53–7.45

Key Findings

  • Five study-level factors associated with hematoma formation were identified.
  • Tumor numbers and higher numbers of cutting passes significantly increased the risk of hematoma.
  • Non-moderate tumor depth (superficial or deep) was linked to hematoma development.
  • A higher vascularity grade was associated with increased hematoma risk.
  • Postoperative compression duration of less than 48 hours correlated with hematoma formation.

Clinical Implications

Clinicians should consider these identified factors when assessing the risk of postoperative hematoma in patients undergoing VAE. The T-P-B framework may assist in structuring perioperative discussions and risk assessments.

Conclusion

This study identifies five factors linked to hematoma development after VAE.

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  4. European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO
  5. Patient experience and healthcare cost aspects of vacuum-assisted excision of breast lesions. A report from the Swedish VAE randomized clinical trial - ScienceDirect
  6. RADAR – Utilizing Radiomics in Acute Subdural Hematoma: Forecasting Outcomes Based on Surface Area
  7. European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO
  8. Patient experience and healthcare cost aspects of vacuum-assisted excision of breast lesions. A report from the Swedish VAE randomized clinical trial - ScienceDirect
  9. Risk factors for hematoma formation after ultrasound-guided vacuum-assisted excision of breast fibroadenoma: An analysis based on ultrasound features - Yunyun Dong, Yuqing Huang, Xinyu Zhao, Lanyan Qiu, Yu Yang, Xian-Quan Shi, 2025

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