COVID-19 Vaccination in Pregnancy: Efficacy of Second-Generation Vaccines, Maternal-Neonatal Safety, and Strategies to Address Vaccine Hesitancy

By
Xu, Jia
Liu, Fang
Yuan, Han-Ying
Pan, Heng
Xi, Xuan
Chen, Che
Li, De-Hong
LU, Yan
May 22, 2026
0 min

Frontiers In Medicine

Overview

This report evaluates the effectiveness and safety of newer COVID-19 vaccines for pregnant women, highlighting the increased risks associated with SARS-CoV-2 infection during pregnancy. It addresses vaccine hesitancy and the need for improved vaccination strategies to protect maternal and neonatal health.

Background

The COVID-19 pandemic has significantly impacted public health, particularly among pregnant women who are at increased risk for severe disease due to physiological changes during pregnancy. Vaccination can mitigate these risks, yet hesitancy persists due to concerns about safety for both mothers and infants. Understanding the effectiveness of vaccines and addressing barriers to uptake is crucial for improving health outcomes in this vulnerable population.

Data Highlights

No specific numerical data provided in the source material.

Key Findings

Pregnant women are at higher risk for severe COVID-19 outcomes, including ICU admission and maternal mortality.
Robust evidence supports the safety and efficacy of COVID-19 vaccines during pregnancy.
Vaccine hesitancy among pregnant women is influenced by concerns over potential adverse effects and fetal safety.
Maternal mRNA vaccination is associated with reduced COVID-19-related hospitalization in infants up to 6 months of age.
Current guidelines recommend COVID-19 vaccination for pregnant individuals, emphasizing the importance of vaccination at the earliest opportunity.

Clinical Implications

Healthcare providers should actively address vaccine hesitancy by providing evidence-based information on the safety and efficacy of COVID-19 vaccines during pregnancy. Ensuring equitable access to vaccination and refining protocols are essential to protect maternal and neonatal health.

Conclusion

Vaccination against COVID-19 is critical for pregnant women to reduce the risks associated with SARS-CoV-2 infection. Ongoing efforts to enhance vaccine uptake and address hesitancy are necessary for improving health outcomes in this population.