Atypical subcutaneous nodule-type paragonimiasis in 3 children: case series - Report - MDSpire

Atypical subcutaneous nodule-type paragonimiasis in 3 children: case series

  • By

  • Zhaokun Guo

  • Ying Jiang

  • Keheng Deng

  • Jun Zhou

  • Pan Jiao

  • Wenxiang Zhu

  • Zhongjing Zhang

  • Xiangyou Zhao

  • July 16, 2026

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Clinical Report: Uncommon Subcutaneous Nodule Presentation of Paragonimiasis

Background

Paragonimiasis is a neglected tropical disease caused by food-borne zoonotic parasites, primarily transmitted through the consumption of raw or undercooked freshwater crustaceans. Its clinical manifestations can vary significantly, often leading to misdiagnosis due to non-specific symptoms.

Data Highlights

PatientAgeEosinophil PercentageParagonimus Antibodies
18 years 10 months24.6%Positive
25 years 4 months44.5%Positive
36 years 3 months31.8%Positive

Key Findings

  • All patients had a clear epidemiological history related to paragonimiasis.
  • Significantly elevated peripheral blood eosinophils were observed in all cases.
  • All patients tested positive for Paragonimus antibodies.
  • Oral praziquantel was administered as part of the treatment.
  • Surgery was performed in two cases.
  • Clinical symptoms of paragonimiasis can mimic other conditions.

Clinical Implications

Elevated eosinophil counts and positive serological tests for Paragonimus can aid in diagnosis.

Conclusion

Atypical presentations of paragonimiasis, such as subcutaneous nodules, require clinical evaluation.

Related Resources & Content

  1. WHO, Neglected tropical diseases: Paragonimiasis, 2025 -- Paragonimiasis Overview
  2. BMC Infectious Diseases, 2025 -- Analysis of clinical characteristics of 213 clinically diagnosed pediatric patients with paragonimiasis from Yunnan, China
  3. Cureus, 2025 -- Subcutaneous Migration in Paragonimiasis as a Diagnostic Clue in an Unusual Presentation
  4. The Journal of Clinical Endocrinology & Metabolism — Evaluating Pediatric Patients with Potential Pheochromocytoma or Paraganglioma in Comparison to Neuroblastoma
  5. Frontiers in Oncology — Case Report: A rare pediatric case of secretory carcinoma of the parotid gland with high-grade components misdiagnosed as pleomorphic adenoma
  6. Frontiers in Pediatrics — Case Report: Pediatric mediastinal actinomycosis mimicking lymphoma diagnosed by tissue metagenomic next-generation sequencing
  7. Frontiers in Pediatrics — Case Report: Pediatric nasopharyngeal carcinoma masquerading as benign lymphadenopathy: diagnostic pitfalls in two cases
  8. Clinical Overview of Paragonimiasis | CDC
  9. Neglected tropical diseases: Paragonimiasis
  10. Analysis of clinical characteristics of 213 clinically diagnosed pediatric patients with paragonimiasis from Yunnan, China | BMC Infectious Diseases | Springer Nature Link
  11. Subcutaneous Migration in Paragonimiasis as a Diagnostic Clue in an Unusual Presentation: A Case Report | Cureus
  12. https://www.icjournal.org/pdf/10.3947/ic.2025.0107

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