Epidemiology of retinopathy of prematurity (ROP) in Northwest China: a decade-long retrospective single-center analysis (2015–2024) - Report - MDSpire

Trends in the Epidemiology of Retinopathy of Prematurity in Northwest China: A Ten-Year Retrospective Study from a Single Center (2015–2024)

  • By

  • Jing Yang

  • Le Zhang

  • July 21, 2026

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Clinical Report: Trends in the Epidemiology of Retinopathy of Prematurity in Northwest China

Overview

This study analyzes the incidence trends of retinopathy of prematurity (ROP) over a decade at a single center in Northwest China.

Background

Retinopathy of prematurity is a significant cause of childhood blindness, affecting premature infants globally. The incidence of ROP varies widely, and despite advancements in neonatal care, the disease remains prevalent. Effective screening is crucial for early detection and treatment.

Data Highlights

Gestational Age (GA)ROP Incidence RateTreatment-Requiring Rate
GA <28 weeks72.37%33.00%
GA 28–<32 weeks23.04%1.39%
GA ≥32 weeks6.17%0.12%

Key Findings

  • The overall ROP incidence rate was 14.18% across the study period.
  • A total of 12,640 infants underwent 31,605 screenings, averaging 2.44 screenings per infant.
  • ROP burden decreased significantly with increasing gestational age.
  • Annual screening volume and treatment demand showed fluctuating upward trends over the decade.

Clinical Implications

The findings suggest that infants with GA <28 weeks require intensive screening, while those with GA ≥32 weeks may have reduced screening frequency. This approach could optimize resource allocation while ensuring high-risk infants are adequately monitored.

Conclusion

The study underscores the ongoing challenges in ROP screening and the need for tailored strategies to improve outcomes for premature infants.

Related Resources & Content

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  2. Frontiers in Pediatrics, 2026 -- Analysis of influencing factors for progression from type 2 to type 1 in retinopathy of prematurity
  3. Frontiers in Pediatrics, 2026 -- Survival without major morbidity in extremely preterm infants: a prospective multicenter study in Shenzhen, China
  4. Screening Examination of Premature Infants for Retinopathy of Prematurity | Pediatrics | American Academy of Pediatrics
  5. International Classification of Retinopathy of Prematurity, Third Edition - Ophthalmology
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  7. RCPCH Screening of retinopathy of prematurity guideline template
  8. Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers - PMC
  9. Screening Examination of Premature Infants for Retinopathy of Prematurity | Pediatrics | American Academy of Pediatrics
  10. International Classification of Retinopathy of Prematurity, Third Edition - Ophthalmology
  11. Telemedicine Utilization for Retinopathy of Prematurity Screening in Premature Infants: Systematic Review and Meta-Analysis - ScienceDirect
  12. Multicenter trial of cryotherapy for retinopathy of prematurity: preliminary results. Cryotherapy for Retinopathy of Prematurity Cooperative Group - PubMed
  13. Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of Prematurity | New England Journal of Medicine
  14. Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW): five-year outcomes of a randomised trial - PubMed
  15. Effect of Intravitreal Aflibercept vs Laser Photocoagulation on Treatment Success of Retinopathy of Prematurity: The FIREFLEYE Randomized Clinical Trial | Trials | JAMA | JAMA Network
  16. Recurrence of Retinopathy of Prematurity Following Anti-vascular Endothelial Growth Factor (Anti-VEGF) Therapy: A Systematic Review and Meta-Analysis - PubMed
  17. Time Course of Retinopathy of Prematurity Regression and Reactivation After Treatment with Ranibizumab or Laser in the RAINBOW Trial - ScienceDirect
  18. 早产儿视网膜病预防管理专家共识(2024) 中华医学会围产医学分会

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