Clinical efficacy of Jianqiao ancient moxibustion in treating chronic fatigue syndrome: a single-center randomized controlled superiority trial protocol - Report - MDSpire

Clinical efficacy of Jianqiao ancient moxibustion in treating chronic fatigue syndrome: a single-center randomized controlled superiority trial protocol

  • By

  • Qimiao Hu

  • Bonuo Qi

  • Yingjun Liu

  • Haijuan Zhang

  • Yulin Liu

  • Yuping Yang

  • Chao Wang

  • June 26, 2026

  • 0 min

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Clinical Report: Efficacy of Ancient Jianqiao Moxibustion for Chronic Fatigue Syndrome

Background

Chronic fatigue syndrome (CFS) is a debilitating condition affecting millions worldwide, characterized by persistent fatigue and various secondary symptoms. Moxibustion, a common TCM practice, is being investigated for its potential benefits in alleviating CFS symptoms.

Data Highlights

ParameterDetails
Study DesignSingle-center, single-blind randomized controlled superiority trial
Participants90 patients with CFS and spleen–kidney yang deficiency
InterventionJianqiao ancient moxibustion vs. moxa box moxibustion
Treatment Frequency3 times per week for 4 weeks
Primary Outcome MeasureFatigue Scale-14
Follow-up Duration16 weeks

Key Findings

  • The trial will assess the efficacy of Jianqiao ancient moxibustion compared to moxa box moxibustion.
  • Participants will be evaluated using multiple scales, including the Fatigue Scale-14 and the Spleen–Kidney Yang Deficiency Symptom Scale.
  • Infrared thermal imaging will be utilized to study changes in thermal characteristics post-treatment.
  • The study aims to provide insights into the mechanisms of moxibustion in CFS management.

Clinical Implications

The findings from this trial may contribute to the understanding of effective non-pharmacological treatments for CFS. If successful, Jianqiao ancient moxibustion could be integrated into therapeutic strategies for patients with spleen–kidney yang deficiency.

Conclusion

This trial aims to clarify the clinical efficacy of Jianqiao ancient moxibustion in treating CFS.

Related Resources & Content

  1. Frontiers in Psychiatry, 2026 -- Moxibustion for gastrointestinal cancer-related fatigue: study protocol for a randomized clinical trial
  2. Frontiers in Neurology, 2026 -- Efficacy of acupuncture-based traditional Chinese medicine therapies for chronic fatigue syndrome: a systematic review and meta-analysis
  3. Frontiers in Oncology, 2026 -- Effectiveness of acupuncture for cancer-related fatigue: a systematic reviews and meta-analysis
  4. CDC, 2024 -- Diagnosing ME/CFS | ME/CFS | CDC
  5. NICE, 2021 -- Recommendations | Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management
  6. Cochrane, 2024 -- Exercise as treatment for adults with chronic fatigue syndrome
  7. Frontiers in Cardiovascular Medicine — Correction: A multi-center, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of Fuzheng Yangxin Granule in treating heart failure with preserved ejection fraction (Qi-Yin deficiency and blood stasis syndrome): study protocol
  8. Diagnosing ME/CFS | ME/CFS | CDC
  9. Recommendations | Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management | Guidance | NICE
  10. Exercise as treatment for adults with chronic fatigue syndrome | Cochrane

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