Link Between Triglyceride Glucose-Waist-to-Height Ratio and Stroke Risk in Middle-Aged and Older Chinese Adults - Report - MDSpire

Link Between Triglyceride Glucose-Waist-to-Height Ratio and Stroke Risk in Middle-Aged and Older Chinese Adults

  • By

  • Jian Yang

  • Jie Liu

  • Zhongyao Liu

  • December 29, 2025

  • 0 min

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Link Between Triglyceride Glucose-Waist-to-Height Ratio and Stroke Risk

Overview

This study investigates the relationship between the triglyceride glucose-waist-to-height ratio (TyG-WHtR) and stroke risk in middle-aged and older Chinese adults. Findings suggest that TyG-WHtR may serve as a significant predictor of stroke risk, potentially outperforming traditional measures.

Background

Stroke is a leading cause of death and long-term disability globally, necessitating effective risk assessment and intervention strategies. Insulin resistance has emerged as a critical predictor of stroke risk, with the triglyceride-glucose index being a commonly used measure. The TyG-WHtR combines lipid and anthropometric data, offering a potentially enhanced predictive capability for cardiovascular events.

Data Highlights

No numerical data provided in the article.

Key Findings

  • The TyG-WHtR is a composite measure that may provide better stroke risk prediction than traditional metrics.
  • Insulin resistance is a significant predictor of stroke risk, with the TyG index showing strong associations.
  • Previous studies indicate that TyG-WHtR is linked to various health conditions, including nonalcoholic fatty liver disease and cardiovascular risk.
  • Longitudinal studies are needed to fully understand the implications of TyG-WHtR on stroke risk over time.
  • Effective screening for stroke risk factors is crucial for reducing incidence rates and healthcare costs.

Clinical Implications

Healthcare professionals should consider incorporating the TyG-WHtR into routine assessments for stroke risk in middle-aged and older adults. This measure may enhance the identification of individuals at high risk, allowing for targeted interventions.

Conclusion

Highlight specific types of further research needed to validate TyG-WHtR's clinical utility.

References

  1. Frontiers in Endocrinology, 2026 -- Links Between Cholesterol, High-Density Lipoprotein, Glucose Index, and Triglyceride-Glucose Indices with Carotid Atherosclerosis in Young and Middle-Aged Adults
  2. Clinical Research in Cardiology, 2025 -- Linking the C-reactive protein-triglyceride glucose index (CTI) to cardiovascular and overall mortality risk in older adults: findings from three datasets
  3. Frontiers in Endocrinology, 2026 -- Beyond the triglyceride-glucose index, the cholesterol- high-density lipoprotein -glucose index as a superior predictor for diabetes risk in patients with major adverse cardiovascular events: dual evidence from the CHARLS database and real-world data
  4. Hub - 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association
  5. Association of triglyceride-glucose index and its related parameters with the risk of stroke: a meta-analysis - PMC
  6. BMC Psychiatry (Springer) — Gender-Based Variations in the Link Between Relative Fat Mass and Cognitive Decline Among Hospitalized Middle-Aged and Older Individuals with Type 2 Diabetes in China: A Cross-Sectional Study at a Single Center
  7. Hub - 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association - Professional Heart Daily | American Heart Association
  8. Association of triglyceride-glucose index and its related parameters with the risk of stroke: a meta-analysis - PMC
  9. First study with positive cardiovascular outcome in obesity: Reflections on SELECT - PMC

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