Dietary background, serum polyunsaturated fatty acid profiles, and 1-year outcomes after large-artery atherosclerotic stroke: a multicenter cohort study - Report - MDSpire

Dietary background, serum polyunsaturated fatty acid profiles, and 1-year outcomes after large-artery atherosclerotic stroke: a multicenter cohort study

  • By

  • Xiaoci Lin

  • Zhihao Zhao

  • Daijun Zhu

  • Guogu Shen

  • Xuri Xu

  • Yinyan Li

  • July 10, 2026

  • 0 min

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Clinical Report: Influence of Long-Term Dietary Habits on Stroke Outcomes

Overview

This study investigates the association between long-term dietary habits and post-stroke outcomes in patients with large-artery atherosclerotic cerebral infarction (LAA-CI). It finds differences in neurological and functional recovery between a high-fish/seafood diet and a mixed/omnivorous diet, with serum polyunsaturated fatty acid (PUFA) profiles being assessed.

Background

Stroke is a leading cause of long-term disability, particularly large-artery atherosclerotic cerebral infarction (LAA-CI) in Asian populations. Understanding modifiable factors, such as dietary habits, is important for post-stroke recovery. This study investigates the impact of dietary patterns and serum PUFA levels on recovery outcomes in stroke patients.

Data Highlights

Dietary GroupmRS ScorePoor Functional OutcomePost-Stroke DepressionCognitive Impairment
High-Fish/SeafoodLowerLower IncidenceLower RatesLower Rates
Mixed/OmnivorousHigherHigher IncidenceHigher RatesHigher Rates

Key Findings

  • Patients with a high-fish/seafood diet had lower mRS scores at 1-year follow-up.
  • Lower incidence of poor functional outcomes was observed in the high-fish/seafood group.
  • Higher ω-3 levels and lower ω-6/ω-3 ratios were found in the high-fish/seafood group.
  • Higher ω-6/ω-3 ratios were associated with increased risks of poor functional outcomes and post-stroke depression.
  • Neurological improvement was noted in the high-fish/seafood dietary group.

Clinical Implications

The findings indicate that dietary habits, particularly the consumption of fish and seafood, may influence recovery outcomes in stroke patients.

Conclusion

Long-term dietary habits impact post-stroke recovery, with the ω-6/ω-3 ratio identified as a potential metabolic marker for outcomes.

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