Clinical Report: Comparison of Tigertriever and Self-Expanding Stent-Retrievers

Overview

This systematic review and meta-analysis evaluated the efficacy and safety of the Tigertriever compared to conventional self-expanding stent retrievers (SE-SRs) in mechanical thrombectomy for large vessel occlusions.

Background

Mechanical thrombectomy is the standard treatment for acute ischemic stroke caused by large vessel occlusions. The introduction of radially adjustable devices like the Tigertriever aims to enhance clot engagement and reduce complications associated with fixed radial force devices.

Data Highlights

Key Findings

• Tigertriever achieved a successful reperfusion rate of 82.8% compared to 77.8% for SE-SRs.
• The odds ratio for successful reperfusion with Tigertriever was 1.74 (95% CI: 1.07–2.83).
• There was a trend towards fewer procedural adverse events with Tigertriever (17.1% vs. 27.4%), but this was not statistically significant.
• Rates of symptomatic intracranial hemorrhage, functional independence, and mortality at 90 days were similar between the two devices.
• The overall risk of bias in the included studies was assessed as low to moderate.
• GRADE-assessed certainty for different outcomes was overall moderate.

Clinical Implications

The findings suggest that the Tigertriever may provide a higher rate of successful reperfusion in mechanical thrombectomy for large vessel occlusions. However, clinicians should consider the comparable safety and functional outcomes when selecting devices for thrombectomy procedures.

Conclusion

This meta-analysis indicates that the Tigertriever offers improved reperfusion rates, while the safety and functional outcomes remain comparable to those of conventional self-expanding stent retrievers.

Related Resources & Content

1. Author(s)/Org, Source, Year -- Title
2. Frontiers in Neurology, 2026 -- Procedure-related vasospasm and reperfusion vulnerability during mechanical thrombectomy
3. Evaluation of Immediate Versus Delayed Stenting Following Thrombectomy Failure in Patients with Intracranial Atherosclerosis-Induced Large Vessel Occlusion
4. Frontiers in Neurology, 2026 -- Long-term outcomes of endovascular thrombectomy vs. medical care in patients with large ischemic stroke: a systematic review and meta-analysis of randomized controlled trials
5. Large-Core Ischemic Stroke Endovascular Treatment: A Science Advisory From the American Heart Association
6. Endovascular treatment for medium or distal vessel occlusion stroke (DISTAL): 12-month outcomes of a multicentre, open-label, randomised trial
7. European Stroke Organisation (ESO) – European Society for Minimally Invasive Neurological Therapy (ESMINT) Guidelines on Mechanical
8. FDA 510(k) clearance letter for Rapid Medical Ltd.
9. New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter TIGER Trial
10. Mechanical thrombectomy of large vessel occlusion using adjustable vs. self-expanding stent-retriever—Comparison of Tigertriever device with stent-like stent-retrievers: A propensity score analysis
11. ABSTRACT NUMBER: ESOC2026LB146 LB146 - FINAL RESULTS OF THE DISTALS (DISTAL ISCHEMIC STROKE TREATMENT WITH ADJUSTABLE LOW-PROFILE STENTRIEVER) RANDOMIZED TRIAL OF TIGERTRIEVER 13-EVT FOR DMVO
12. Large-Core Ischemic Stroke Endovascular Treatment: A Science Advisory From the American Heart Association
13. Endovascular treatment for medium or distal vessel occlusion stroke (DISTAL): 12-month outcomes of a multicentre, open-label, randomised trial - ScienceDirect
14. European Stroke Organisation (ESO) – European Society for Minimally Invasive Neurological Therapy (ESMINT) Guidelines on Mechanical
15. FDA 510(k) clearance letter for Rapid Medical Ltd.
16. New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter TIGER Trial - PMC
17. Mechanical thrombectomy of large vessel occlusion using adjustable vs. self-expanding stent-retriever—Comparison of Tigertriever device with stent-like stent-retrievers: A propensity score analysis - PMC
18. ABSTRACT NUMBER: ESOC2026LB146 LB146 - FINAL RESULTS OF THE DISTALS (DISTAL ISCHEMIC STROKE TREATMENT WITH ADJUSTABLE LOW-PROFILE STENTRIEVER) RANDOMIZED TRIAL OF TIGERTRIEVER 13-EVT FOR DMVO - PMC