The effect of pectin-supplemented enteral nutrition in mechanically ventilated patients receiving gastric feeding: protocol of a multicenter, open-label, randomized controlled trial (the PROMOTE trial) - Report - MDSpire
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The effect of pectin-supplemented enteral nutrition in mechanically ventilated patients receiving gastric feeding: protocol of a multicenter, open-label, randomized controlled trial (the PROMOTE trial)
Clinical Report: Investigating the Impact of Pectin-Enriched Enteral Nutrition
Overview
The PROMOTE trial evaluates the efficacy of pectin-enriched enteral nutrition (EN) in improving feeding tolerance among mechanically ventilated patients.
Background
Enteral nutrition is crucial for critically ill patients, yet feeding intolerance affects a significant portion of this population, leading to serious complications. Current management strategies for feeding intolerance are often inadequate, highlighting the need for effective interventions. Pectin, a water-soluble dietary fiber, may improve feeding tolerance.
Data Highlights
No numerical data available in the provided source material.
Key Findings
The PROMOTE trial is a multicenter, open-label, randomized controlled trial conducted in 10 centers across China.
Patients in the intervention group will receive EN supplemented with 90 g of pectin per 500 mL of EN solution.
The primary outcome is the ratio of EN energy intake to prescribed target energy on Day 5 after randomization.
Secondary outcomes include daily energy and protein intake, incidence of feeding intolerance, and duration of ICU and hospital stays.
Clinical Implications
The findings from the PROMOTE trial may inform clinical practices regarding the use of pectin in enteral nutrition for critically ill patients. If effective, pectin supplementation could enhance feeding tolerance and optimize nutritional delivery in this vulnerable population.
Conclusion
The PROMOTE trial aims to provide robust evidence on the role of pectin in enteral nutrition, potentially guiding future nutritional strategies in critical care settings.
