Dynamic changes in serum albumin, prealbumin, and retinol-binding protein after head and neck cancer surgery: a retrospective cohort study - Report - MDSpire
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Dynamic changes in serum albumin, prealbumin, and retinol-binding protein after head and neck cancer surgery: a retrospective cohort study
Postoperative Fluctuations in Serum Albumin, Prealbumin, and Retinol-Binding Protein Levels
Overview
This study analyzed serum albumin, prealbumin, and retinol-binding protein levels in head and neck cancer patients before and after surgery.
Background
Nutritional status is critical in patients with head and neck malignancies due to the catabolic effects of tumors and surgical stress. Traditional markers like serum albumin may not adequately reflect short-term changes in nutritional status. This study aims to analyze the effectiveness of different nutritional support strategies during the perioperative period.
Data Highlights
Group
ALB (g/dL)
PA (mg/dL)
RBP (mg/dL)
CRP (mg/L)
NLR
Hospital Stay (days)
Control
Pre-op: X
Pre-op: Y
Pre-op: Z
Pre-op: A
Pre-op: B
Pre-op: C
Intervention
Post-op: X'
Post-op: Y'
Post-op: Z'
Post-op: A'
Post-op: B'
Post-op: C'
Key Findings
Intervention group had higher levels of ALB, PA, and RBP postoperatively (p < 0.05).
CRP and NLR levels were significantly lower in the intervention group (p < 0.05).
The intervention group experienced a shorter time to first oral intake (p < 0.05).
Hospital stay was shorter in the intervention group (p < 0.05).
Energy and protein target achievement rates were higher in the intervention group on postoperative days 3 and 7 (p < 0.05).
PA and RBP were more sensitive indicators for perioperative nutritional assessment than ALB.
Clinical Implications
The findings suggest that intensive nutritional intervention can enhance postoperative recovery and nutritional status in head and neck cancer patients. Clinicians should consider using multiple biomarkers, including PA and RBP, for a more accurate assessment of nutritional needs during the perioperative period.
Conclusion
Intensive nutritional support improves key nutritional biomarkers and reduces inflammatory responses in head and neck cancer patients post-surgery.
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