Evaluation of Donor Vessel Using Quantitative Flow Ratio in Patients with Chronic Total Occlusions - Report - MDSpire

Evaluation of Donor Vessel Using Quantitative Flow Ratio in Patients with Chronic Total Occlusions

  • By

  • Xinjian Li

  • Juntao Duan

  • Lin Mi

  • Liyuan Tao

  • Xinye Xu

  • Guisong Wang

  • March 12, 2026

  • 0 min

Share

Evaluation of Donor Vessel Using Quantitative Flow Ratio in Patients with CTO

Overview

This study evaluates the agreement between µQFR and 3D-QFR in assessing donor vessels in patients with chronic total occlusions (CTOs). Findings suggest that µQFR, which requires only a single angiographic projection, may be a feasible alternative for functional assessment in this patient population.

Background

Chronic total occlusions (CTOs) are prevalent in obstructive coronary artery disease, affecting approximately 25% of patients. The assessment of collateral circulation, particularly the predominant collateral donor artery (PCDA), is crucial as it can influence myocardial ischemia and treatment strategies. Functional assessment methods like quantitative flow ratio (QFR) are essential for guiding revascularization decisions in these complex cases.

Data Highlights

No numerical data provided in the source material.

Key Findings

  • µQFR is a novel method that requires only a single angiographic projection for assessment.
  • 3D-QFR typically requires two projections, which can be challenging in CTO cases.
  • The study aimed to explore the agreement between µQFR and 3D-QFR specifically for donor vessels.
  • Functional assessment of donor vessels is recommended in current clinical guidelines for coronary artery disease management.
  • Previous studies have shown high diagnostic accuracy of QFR in identifying significant coronary stenosis.

Clinical Implications

The findings support the use of µQFR as a practical tool for assessing donor vessels in CTO patients, potentially improving the feasibility of functional evaluations in complex coronary anatomies. Clinicians may consider integrating µQFR into their assessment protocols to enhance decision-making for revascularization.

Conclusion

The study highlights the potential of µQFR as a reliable alternative to 3D-QFR for evaluating donor vessels in patients with CTO. This advancement may facilitate better management of coronary artery disease in this challenging patient population.

References

  1. Clinical Research in Cardiology, 2021 -- Quantitative Flow Ratio (QFR) Assesses the Functional Importance of Non-Culprit Lesions in Coronary Angiograms of Acute Myocardial Infarction Patients
  2. Updates in Surgery, 2025 -- Evaluation of Intraoperative Renal Blood Flow Using Transit Time Flow Measurements in Kidney Transplantation from Living and Deceased Donors
  3. European Radiology, 2023 -- Influence of Vessel Structure on CT-Based Fractional Flow Reserve in Non-Obstructive Coronary Artery Disease of the Right Coronary Artery
  4. ACC/AHA Task Force on Clinical Practice Guidelines -- 2023 Chronic Coronary Disease Guideline
  5. Diagnostic Performance of Angiography-Derived Quantitative Flow Ratio: A Systematic Review and Meta-Analysis
  6. Quantitative flow ratio for assessment of donor vessel in patients with chronic total occlusions | BMC Cardiovascular Disorders
  7. European Radiology — Changes Over Time in CT-Based Fractional Flow Reserve Measurements Following Heart Transplantation
  8. ACC/AHA Task Force on Clinical Practice Guidelines
  9. Diagnostic Performance of Angiography-Derived Quantitative Flow Ratio: A Systematic Review and Meta-Analysis
  10. Quantitative flow ratio for assessment of donor vessel in patients with chronic total occlusions | BMC Cardiovascular Disorders | Springer Nature Link

Original Source(s)

Related Content