Study on the correlation between ventricular arrhythmia and heart rate variability in patients with coronary heart disease - Report - MDSpire

Study on the correlation between ventricular arrhythmia and heart rate variability in patients with coronary heart disease

  • By

  • Xin Guan

  • Zhiyue Jia

  • Bing Yang

  • July 15, 2026

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Clinical Report: Investigation of the Relationship Between Ventricular Arrhythmia and Heart Rate Variability in Individuals with Coronary Heart Disease

Overview

This study investigates the correlation between heart rate variability (HRV) and ventricular arrhythmia (VA) in patients with coronary heart disease (CHD). The findings indicate that specific HRV indices are significantly associated with the occurrence of VA.

Background

Ventricular arrhythmia is a common complication in patients with coronary heart disease, which can lead to severe symptoms. Heart rate variability is a measure of autonomic nervous system function and has been linked to various cardiovascular conditions. Understanding the relationship between HRV and VA may provide insights for management of patients with CHD.

Data Highlights

HRV IndexVA GroupControl GroupP-value
SDNNLowerHigher< 0.05
SDANNLowerHigher< 0.05
rMSSDLowerHigher< 0.05
PNN50LowerHigher< 0.05

Key Findings

  • HRV indices SDNN, SDANN, rMSSD, and PNN50 were significantly lower in the VA group compared to the control group.
  • Linear regression analysis indicated that SDANN, rMSSD, and PNN50 were significantly associated with the occurrence of VA.
  • The derived linear equation for predicting VA occurrence was Y = 1.976 − 0.006 × X2 − 0.009 × X3 − 0.007 × X4.

Clinical Implications

Clinicians may consider HRV indices when evaluating patients for arrhythmia risk.

Conclusion

The findings highlight the significant association between HRV indices and the occurrence of ventricular arrhythmia in patients with coronary heart disease.

Related Resources & Content

  1. Clinical Research in Cardiology, 2023 -- Variability in Heart Rate: Clinical Implications and Reference Standards for Mortality in Heart Failure Patients
  2. Frontiers in Medicine, 2026 -- Integrated heart rate and oxygen uptake recovery phenotypes reveal heterogeneous recovery patterns in coronary artery disease
  3. European Journal of Preventive Cardiology -- The timing and relationship of ventricular arrhythmia with exercise patterns in veteran male endurance athletes
  4. 2022 Ventricular Arrhythmias and Sudden Cardiac Death
  5. Which indices of heart rate variability are the best predictors of mortality after acute myocardial infarction? Meta-analysis of observational studies, 2024
  6. Pediatric Cardiology — Assessment of Heart Rate Variability and Atrial Function in Pediatric Patients Following Long-Term Evaluation Post Atrioventricular Node Slow-Pathway Radiofrequency Ablation
  7. 2022 Ventricular Arrhythmias and Sudden Cardiac Death
  8. Which indices of heart rate variability are the best predictors of mortality after acute myocardial infarction? Meta-analysis of observational studies - ScienceDirect
  9. The Utility of Coronary Revascularization to Reduce Ventricular Arrhythmias in Coronary Artery Disease Patients: A Systematic Review - PubMed

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