Patient Profiles and Outcomes in Endometriosis with Malignant or Borderline Ovarian Tumors: Insights from an ESGO Designated Center of Excellence - Report - MDSpire

Patient Profiles and Outcomes in Endometriosis with Malignant or Borderline Ovarian Tumors: Insights from an ESGO Designated Center of Excellence

  • By

  • Maximilian Heinz Beck

  • Paul Kordowitzki

  • Eva Roser

  • Anna Trelinska-Finger

  • Emily Schoof

  • Lukas Chinczewski

  • Sylvia Mechsner

  • Jalid Sehouli

  • April 16, 2026

  • 0 min

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Clinical Report: Patient Profiles and Outcomes in Endometriosis with Ovarian Tumors

Overview

This study evaluates the survival outcomes and clinical characteristics of patients with malignant or borderline ovarian tumors, with a focus on those with concurrent endometriosis. The findings suggest that endometriosis may influence prognosis in ovarian cancer patients.

Background

Endometriosis is a prevalent condition affecting 5-10% of women of reproductive age and is associated with an increased risk of ovarian cancer, particularly type I histotypes. Understanding the relationship between endometriosis and ovarian tumors is crucial for improving patient management and outcomes.

Data Highlights

No numerical data was provided in the source material.

Key Findings

  • Endometriosis is associated with a 2- to 10-fold increased risk of ovarian cancer.
  • Atypical endometriosis may serve as a premalignant precursor lesion, found in 12-35% of ovarian endometriomas.
  • Concurrent endometriosis at the time of ovarian cancer diagnosis may have prognostic implications.
  • Histological confirmation of endometriosis is essential for accurate diagnosis and treatment planning.
  • Multidisciplinary management is critical for optimal outcomes in ovarian cancer patients.

Clinical Implications

Clinicians should consider the presence of endometriosis when evaluating patients with ovarian tumors, as it may influence treatment decisions and prognostic assessments. Enhanced awareness and monitoring strategies for patients with endometriosis are recommended.

Conclusion

The study underscores the importance of recognizing endometriosis as a potential factor in the prognosis of ovarian cancer, warranting further investigation into its implications for patient management.

References

  1. European Radiology, 2024 -- Imaging and Management Strategies for Ovarian Cancer
  2. European Radiology, 2024 -- Revised Guidelines for Staging and Monitoring Ovarian Cancer
  3. Obesity Surgery, 2024 -- Factors Influencing the Effectiveness of Endoscopic Sleeve Gastroplasty
  4. European Radiology, 2025 -- Consensus Guidelines from ESUR on MRI Protocols for Endometriosis
  5. JAMA, 2024 -- Endometriosis and Ovarian Cancer
  6. Endometriosis and Ovarian Cancer Risk
  7. The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysis - PMC

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