Clinical Report: Association of Cholesterol, HDL, and Glucose Index with HRV

Overview

This study investigates the relationship between the cholesterol, high-density lipoprotein, and glucose (CHG) index and heart rate variability (HRV) in patients with chronic coronary syndromes (CCS) and anxiety. Elevated CHG is associated with increased risk of 1-year cardiovascular rehospitalization, highlighting the importance of metabolic and autonomic factors in this population.

Background

Chronic coronary syndromes (CCS) are a significant cause of morbidity and mortality, often exacerbated by comorbid anxiety. Metabolic dysregulation, particularly involving cholesterol and glucose levels, may contribute to adverse cardiovascular outcomes. Understanding the interplay between metabolic markers and heart rate variability (HRV) can enhance risk stratification and management strategies for patients with CCS and anxiety.

Data Highlights

Key Findings

• Patients in the highest CHG quartile had significantly lower HRV_z compared to those in the lowest quartile.
• Each 1-unit increase in CHG was associated with a higher risk of 1-year cardiovascular rehospitalization.
• Exploratory analyses indicated that higher HRV_z correlated with a lower risk of rehospitalization.
• Nonlinear associations were observed between CHG, HRV_z, and rehospitalization risk.
• Complete-case sensitivity analyses supported the main findings, though caution is advised in interpreting HRV-related results.

Clinical Implications

The findings suggest that monitoring the CHG index and HRV_z may provide valuable insights for risk assessment in patients with CCS and anxiety. Clinicians should consider these factors when developing management plans to reduce rehospitalization risk in this vulnerable population.

Conclusion

Elevated CHG is linked to increased cardiovascular rehospitalization risk in patients with CCS and anxiety, emphasizing the need for integrated metabolic and autonomic assessments in clinical practice.

Related Resources & Content

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2. Frontiers in Endocrinology, 2026 -- Beyond the triglyceride-glucose index, the cholesterol- high-density lipoprotein -glucose index as a superior predictor for diabetes risk in patients with major adverse cardiovascular events: dual evidence from the CHARLS database and real-world data
3. European Journal of Preventive Cardiology -- Anxiety and depression and secondary prevention of coronary heart disease in 14 countries across six WHO regions: the INTERASPIRE study
4. Clinical Research in Cardiology -- Longitudinal and Mendelian Randomization Analysis of Heart Rate Variability's Relationship with Atrial Fibrillation in the General Population
5. New Chronic Coronary Syndrome (CCS) Guidelines expand diagnostic tools and ways to prevent major adverse events and enhance quality of life
6. Heart rate variability, unstable coronary plaques, and cardiovascular outcomes | European Heart Journal
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8. Heart rate variability, unstable coronary plaques, and cardiovascular outcomes | European Heart Journal | Oxford Academic
9. Triglyceride-glucose index variability and risk of all-cause and cardiovascular mortality | Scientific Reports