Association of preoperative CT-derived visceral adipose tissue index with synchronous metastasis and metastasis-free survival after curative-intent surgery in colorectal cancer - Report - MDSpire
Advertisement
Association of preoperative CT-derived visceral adipose tissue index with synchronous metastasis and metastasis-free survival after curative-intent surgery in colorectal cancer
Clinical Report: Relationship Between Preoperative VATI and Metastasis in CRC
Overview
This study investigates the association of preoperative CT-derived visceral adipose tissue index (VATI) with synchronous metastasis and metastasis-free survival (MFS) in colorectal cancer (CRC) patients. Findings indicate that higher VATI correlates with increased risk of synchronous metastasis and shorter MFS following curative surgery.
Background
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality globally, with metastasis significantly impacting treatment outcomes. Identifying patients at high risk for metastasis is crucial for optimizing management and surveillance strategies. The visceral adipose tissue index (VATI) may serve as a valuable biomarker for risk stratification in CRC patients undergoing surgery.
Data Highlights
Metric
Value
Patients included
468
Metastatic CRC patients
77
Non-metastatic CRC patients
391
High-VATI group MFS
Shorter (log-rank p = 0.001)
VATI OR for synchronous metastasis
1.110 (95% CI, 1.067–1.155; p < 0.001)
VATI HR for MFS
1.017 (95% CI, 1.003-1.032; p = 0.021)
Key Findings
Higher VATI is independently associated with synchronous metastasis in CRC patients.
The high-VATI group exhibited significantly shorter metastasis-free survival (MFS) compared to the low-VATI group.
VATI remains a significant predictor of MFS after adjusting for other clinical factors such as CA19-9 and CEA levels.
No significant differences in body composition metrics were found between early and late metastasis groups.
VATI could enhance risk stratification and postoperative surveillance in CRC, pending further validation.
Clinical Implications
Preoperative assessment of VATI via CT may provide clinicians with a useful tool for identifying CRC patients at higher risk of metastasis. Incorporating VATI into routine evaluations could refine postoperative surveillance strategies and improve patient outcomes.
Conclusion
The study highlights the potential of preoperative VATI as a prognostic biomarker in CRC, warranting further investigation to establish its role in clinical practice.
