Clinical Report: Investigation of Epicardial Adipose Tissue and Hypertension
Overview
This study explores the relationship between epicardial adipose tissue (EAT) and hypertension using photon-counting CT and radiomic analysis. The findings indicate a lower mean EAT attenuation in hypertensive patients.
Background
Epicardial adipose tissue (EAT) is linked to cardiovascular diseases and risk factors. The advent of photon-counting computed tomography (PCCT) enhances the evaluation of EAT, allowing for more precise assessment.
Data Highlights
No numerical data provided in the article.
Key Findings
The study involved 114 patients without coronary artery disease.
Patients were categorized based on the presence or absence of arterial hypertension.
Logistic regression achieved a cross-validated AUC of 0.65 and a held-out test AUC of 0.59.
The most significant finding was a lower mean EAT attenuation in the hypertension group.
Feature selection utilized univariate analysis, recursive feature elimination, and random forest importance.
Results are exploratory and require validation in larger cohorts.
Clinical Implications
Further validation in larger studies is necessary to confirm these exploratory results.
Conclusion
This investigation highlights the findings related to EAT and hypertension, warranting further research for validation.
Higher annual oral corticosteroid exposure was associated with greater odds of systemic adverse events, with avascular bone necrosis and pneumonia showing dose-dependent associations with cumulative dose and osteoporosis associated with longer annual exposure duration.
