Prevalence and associated factors of gestational diabetes mellitus among women with polycystic ovary syndrome: a systematic review and meta-analysis - Report - MDSpire
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Prevalence and associated factors of gestational diabetes mellitus among women with polycystic ovary syndrome: a systematic review and meta-analysis
Clinical Report: Assessment of Gestational Diabetes Mellitus Prevalence in PCOS
Overview
This systematic review and meta-analysis evaluated the prevalence of gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS), finding a pooled prevalence of 24%. Key associated factors included pre-pregnancy BMI, gestational weight gain, HOMA-IR, and family history of diabetes.
Background
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women, with a prevalence of approximately 8% to 13%. Women with PCOS are at an increased risk for gestational diabetes mellitus (GDM), which can lead to adverse outcomes for both mother and child.
Data Highlights
Measure
Value
Pooled GDM Prevalence
24% (95% CI: 20%-28%)
Prevalence by Diagnostic Criteria (One-step)
26.0%
Prevalence by Diagnostic Criteria (Two-step)
18.7%
Pre-pregnancy BMI Odds Ratio
1.39
Gestational Weight Gain Odds Ratio
1.58
HOMA-IR Odds Ratio
3.41
Family History of Diabetes Odds Ratio
2.88
Key Findings
Pooled GDM prevalence in PCOS is 24% with significant heterogeneity (I² = 89.9%).
Primary prevalence estimate from cohort studies is 21.7% (95% CI: 17.7%-25.8%).
GDM prevalence is higher with one-step diagnostic criteria (26.0%) compared to two-step (18.7%).
Pre-pregnancy BMI, gestational weight gain, HOMA-IR, and family history of diabetes are significantly associated with GDM risk.
Substantial variability in GDM prevalence suggests differing risk profiles across populations.
Clinical Implications
Women with PCOS should be considered a high-risk group for gestational diabetes mellitus, necessitating early monitoring of glucose metabolism and weight management. Identifying and addressing associated factors can aid in the development of targeted interventions.
Conclusion
The findings highlight the need for increased awareness and proactive management of gestational diabetes in women with PCOS, given the significant prevalence and associated risk factors identified.
