Trimodal prehabilitation and psychological outcomes in colorectal cancer surgery: preliminary findings from a single-center randomized trial - Report - MDSpire
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Trimodal prehabilitation and psychological outcomes in colorectal cancer surgery: preliminary findings from a single-center randomized trial
Clinical Report: Effects of Trimodal Prehabilitation on Psychological Well-Being
Overview
This study evaluates the impact of a trimodal prehabilitation program on psychological well-being in patients undergoing colorectal cancer surgery. Results indicate significant reductions in anxiety and improvements in perceived health status, although no significant changes in depressive symptoms were observed.
Background
Colorectal cancer surgery is associated with considerable physical and psychological stress, leading to high rates of anxiety and depression among patients. Enhanced Recovery After Surgery (ERAS) protocols aim to improve perioperative outcomes, yet they may not fully address psychological distress. Prehabilitation, which includes exercise, nutrition, and psychological support, represents a proactive approach to enhance recovery and quality of life.
Data Highlights
Outcome
Intervention Group (n=20)
Control Group (n=25)
p-value
GAD-7 Scores (T-4 to T + 52 weeks)
6.2 ± 5.1 to 2.2 ± 3.1
4.7 ± 4.8 to 2.9 ± 2.8
< 0.001
SF-36 “Health Change” at 52 weeks
76.6 ± 26.6
74.8 ± 29.2
< 0.00001
PHQ-9 Scores
Not significant over time
Not significant over time
0.437
EORTC QLQ-C30 Emotional Functioning
Improved (p < 0.05)
Not specified
Not specified
Key Findings
Trimodal prehabilitation significantly reduced anxiety as measured by GAD-7 scores.
Perceived health improvement at 52 weeks was greater in the intervention group compared to controls.
No significant differences were found in depressive symptoms over time between groups.
Improvements were noted in emotional functioning and cancer-related fatigue domains of the EORTC QLQ-C30.
Correlations between baseline physical performance and psychological outcomes were not statistically significant.
Clinical Implications
The findings indicate that incorporating a trimodal prehabilitation program may reduce anxiety and enhance perceived health status in patients undergoing colorectal cancer surgery. However, no significant changes in depressive symptoms were observed.
Conclusion
Trimodal prehabilitation within an ERAS pathway shows potential in improving psychological outcomes for colorectal cancer surgery patients.
