Cognitive impairment and associated factors in elderly patients with schizophrenia: a retrospective observational study with phenotype analysis - Report - MDSpire
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Cognitive impairment and associated factors in elderly patients with schizophrenia: a retrospective observational study with phenotype analysis
Cognitive Dysfunction and Contributing Factors in Older Adults with Schizophrenia
Overview
Expand on the implications of cognitive impairment for treatment adherence and quality of life.
Background
Cognitive impairment is a critical issue in schizophrenia, particularly among the elderly, who face additional challenges from chronic comorbidities and functional decline. Understanding the prevalence and determinants of cognitive impairment in this demographic is essential for developing effective nursing interventions and improving patient outcomes. As the population ages, addressing cognitive dysfunction in elderly patients with schizophrenia becomes increasingly important for healthcare systems.
Data Highlights
Measure
Result
Prevalence of cognitive impairment
47.7%
Odds ratio for higher MSPSS score
0.609 (95% CI: 0.469-0.791, p < 0.001)
Odds ratio for higher ADL score
0.553 (95% CI: 0.379-0.806, p = 0.002)
Odds ratio for diabetes mellitus
7.735 (95% CI: 1.129-52.979, p = 0.037)
Model accuracy
96.6%
Key Findings
The prevalence of cognitive impairment in elderly patients with schizophrenia is 47.7%.
Higher perceived social support is associated with lower odds of cognitive impairment.
Higher activities of daily living (ADL) scores correlate with reduced cognitive impairment risk.
Diabetes mellitus significantly increases the odds of cognitive impairment.
K-means clustering identified three cognitive and psychosocial phenotypes among patients.
Clinical Implications
Healthcare providers should prioritize assessing cognitive function in elderly patients with schizophrenia, considering factors like social support and functional independence. Tailored nursing interventions that address these determinants may improve cognitive outcomes and overall quality of life for this vulnerable population.
Conclusion
Cognitive impairment is a prevalent and multifactorial issue among elderly patients with schizophrenia. Addressing the identified factors can enhance care strategies and patient outcomes.
