Cardiovascular Characteristics of Neonatal Fungal Sepsis: A Retrospective Analysis of Clinical Variability
Clinical Report: Cardiovascular Characteristics of Neonatal Fungal Sepsis
Overview This study evaluates the hemodynamic characteristics of neonatal fungal sepsis, highlighting significant cardiovascular alterations in affected neonates.
Background Neonatal fungal sepsis is a significant cause of late-onset sepsis in preterm and low-birth-weight infants, contributing to high morbidity and mortality rates. Understanding its cardiovascular implications is crucial.
Data Highlights Parameter Active Infection Post-Clearance Tricuspid Annular Plane Systolic Excursion (TAPSE) 6.4 ± 1.2 mm 7.8 ± 2.4 mm Pulmonary Artery Systolic Pressure 28.5 ± 17.3 mmHg 12.8 ± 4.2 mmHg Right Ventricular Output 315.0 ± 49.4 mL/kg/min 246.0 ± 27.1 mL/kg/min Mortality Rate 19.2%
Key Findings 73.1% of the cohort were preterm infants, most with low birth weight. Non-Candida albicans organisms were the majority of fungal isolates. Common clinical features included respiratory deterioration, feed intolerance, and thrombocytopenia. Functional echocardiography revealed significant cardiovascular involvement during active infection. Post-treatment, hemodynamic parameters improved, indicating reversible changes. Left ventricular systolic function remained relatively preserved despite the hemodynamic alterations. Clinical Implications Functional echocardiography may provide insights into the cardiovascular status of neonates with fungal sepsis.
Conclusion Further research is warranted to compare these findings with bacterial sepsis.
Related Resources & Content
Author(s)/Org, Source, Year -- Title The Journal of Infectious Diseases, 2024 -- The Role of the Gut in Fungal Infections Open Forum Infectious Diseases, 2024 -- Assessing the Impact of Neonatal Invasive Candidiasis Surviving Sepsis Campaign International Guidelines, 2026 -- Management of Sepsis the pathologist — Neonatal Sepsis Biomarker Critical Care (Springer) — Microvascular phenotypes in pediatric sepsis identified by machine learning: prognostic implications for organ dysfunction and mortality Neonatal Sepsis Biomarker Microvascular phenotypes in pediatric sepsis Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026 International Consensus Criteria for Pediatric Sepsis and Septic Shock | Critical Care Medicine | JAMA | JAMA Network Recent Challenges in Diagnosis and Treatment of Invasive Candidiasis in Neonates - PMC untitled Clinical Overview of Invasive Candidiasis | Candidiasis | CDC Summary of Major Changes in the 2024 Red Book | Red Book: 2024–2027 Report of the Committee on Infectious Diseases | Red Book Online | American Academy of Pediatrics Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM - ScienceDirect Neonatal sepsis and cardiovascular dysfunction II: assessment | Pediatric Research Guidelines and Recommendations for Targeted Neonatal Echocardiography and Cardiac Point-of-Care Ultrasound in the Neonatal Intensive Care Unit: An Update from the American Society of Echocardiography
