Clinical Report: Investigating the Combined Metabolic and Reproductive Relationships of AMH and TyG Index in PCOS
Overview
This study investigates the associations of anti-Müllerian hormone (AMH) and the triglyceride-glucose (TyG) index with polycystic ovary syndrome (PCOS).
Background
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting a significant percentage of women of reproductive age, characterized by reproductive and metabolic dysregulation.
Data Highlights
Parameter
Odds Ratio (OR)
P-value
AMH
1.252
< 0.05
TyG index
1.981
< 0.05
Interaction
1.029
< 0.001
Low AMH/High TyG
4.561
0.002
Double-high group
12.082
< 0.05
Key Findings
AMH and TyG index are associated with PCOS (ORs = 1.252, 1.981; both P < 0.05).
A significant interaction between AMH and TyG index was identified (OR = 1.029, P < 0.001).
In the low AMH subgroup, a significant positive association with PCOS risk was observed for the TyG index (OR = 4.561, P = 0.002).
Risk for PCOS increased across groups defined by AMH and TyG levels (ORs = 3.582, 5.894, 12.082; all P < 0.05).
The predictive model combining AMH and TyG index showed the highest accuracy (AUC = 0.693).
Clinical Implications
The findings highlight the importance of assessing both AMH and the TyG index in the evaluation of PCOS risk. Clinicians may consider these markers in conjunction to improve risk stratification and management strategies for affected patients.
Conclusion
The study demonstrates that AMH and the TyG index serve as risk factors for PCOS.
