Clinical Report: Temporal Variations in the ALPS Index and Its Clinical Associations

Overview

This study evaluates the DTI-ALPS index's robustness and its correlation with clinical characteristics in patients post-basal ganglia hemorrhage. Findings indicate significant differences in the ALPS index among patient groups.

Background

Spontaneous intracerebral hemorrhage (ICH) is a critical condition that can lead to severe neurological deficits. Understanding the microstructural changes in the brain following such events is essential. The ALPS index serves as a potential imaging biomarker to assess glymphatic function.

Data Highlights

Key Findings

• ALPS index showed significant differences among patient groups (p < 0.05).
• All patient groups had significantly lower ALPS indices compared to healthy controls (p < 0.001).
• No significant correlation was found between ALPS index and Brunnstrom recovery stage for the hand (r = 0.219, p > 0.05).
• A significant negative correlation was observed between ALPS index and hematoma volume in the ≤ 10 mL subgroup (r = −0.529, p < 0.05).
• The consistency of ALPS index measurements between 15-direction and 32-direction DTI data was excellent (ICC = 0.959–0.981, p < 0.05).

Clinical Implications

The ALPS index may serve as a useful imaging biomarker for assessing glymphatic function in patients following basal ganglia hemorrhage.

Conclusion

The study highlights the ALPS index in understanding the impact of basal ganglia hemorrhage on glymphatic function.

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