Baihe Gujin decoction ameliorates sepsis-induced acute lung injury through Nrf2/GPX4-mediated antioxidant defense and PPARα-driven metabolic reprogramming: a multi-omics investigation - Report - MDSpire

Baihe Gujin decoction ameliorates sepsis-induced acute lung injury through Nrf2/GPX4-mediated antioxidant defense and PPARα-driven metabolic reprogramming: a multi-omics investigation

  • By

  • Kaiyuan Zhang

  • Yuqing Huang

  • Yuan Wu

  • Zhitao Yang

  • Fangyu Luo

  • Yu Han

  • Lan Zheng

  • Lingling Lv

  • June 29, 2026

  • 0 min

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Clinical Report: Baihe Gujin Decoction Enhances Antioxidant Defense in Sepsis

Overview

Baihe Gujin decoction (BHGJD) significantly ameliorates sepsis-induced acute lung injury (ALI) by enhancing antioxidant defenses. The study identifies key protective mechanisms involving Nrf2/GPX4 pathways.

Background

Sepsis-induced ALI is a severe complication of sepsis with high mortality rates. Oxidative stress and metabolic disturbances play crucial roles in the pathogenesis of ALI.

Data Highlights

MechanismFindings
Nrf2/GPX4 ActivationImproved redox and mitochondrial homeostasis
PPARα/CPT1A Metabolic RemodelingIncreased fatty acid utilization and mitochondrial respiration
Inflammatory Cytokine ReductionDecreased levels of inflammatory mediators

Key Findings

  • BHGJD improved histological architecture in a CLP mouse model of ALI.
  • Activation of Nrf2/GPX4 pathway was linked to enhanced antioxidant responses.
  • PPARα/CPT1A pathway was associated with metabolic reprogramming toward fatty acid oxidation.
  • Reduction of inflammatory lipid mediators was observed with BHGJD treatment.
  • Altered mTOR signaling may represent a convergent regulatory pathway in the protective effects of BHGJD.

Clinical Implications

Further clinical evaluation is warranted to assess the efficacy of BHGJD in human populations.

Conclusion

BHGJD demonstrates protective effects against sepsis-induced ALI through multiple interconnected mechanisms.

Related Resources & Content

  1. Frontiers in Immunology, 2026 -- Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction
  2. Frontiers in Immunology, 2026 -- Macrophage metabolic reprogramming in sepsis-associated acute lung injury: mechanisms and therapeutic strategies
  3. Frontiers in Immunology, 2026 -- Immunometabolic reprogramming and glycolysis-associated signatures in sepsis: insights from single-cell RNA sequencing and machine learning
  4. Surviving Sepsis Campaign Adult Guidelines | SCCM
  5. The Journal of Infectious Diseases — Correction to: CircEXOC5 Aggravates Sepsis-Induced Acute Lung Injury by Promoting Ferroptosis Through the IGF2BP2/ATF3 Axis
  6. Surviving Sepsis Campaign Adult Guidelines | SCCM
  7. An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome: An Official American Thoracic Society Clinical Practice Guideline - PMC
  8. Targeting ferroptosis offers therapy choice in sepsis-associated acute lung injury - ScienceDirect

Original Source(s)

Baihe Gujin decoction ameliorates sepsis-induced acute lung injury through Nrf2/GPX4-mediated antioxidant defense and PPARα-driven metabolic reprogramming: a multi-omics investigation

  • by Kaiyuan Zhang, Yuqing Huang, Yuan Wu, Zhitao Yang, Fangyu Luo, Yu Han, Lan Zheng, Lingling Lv

  • June 29, 2026

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