Factors Influencing Thrombocytopenia in Critically Ill Individuals

Overview

This systematic review and meta-analysis identifies key factors associated with thrombocytopenia in critically ill patients, including bleeding, sepsis, and impaired liver function.

Background

Thrombocytopenia is a prevalent hematological issue in critically ill patients, often linked to severe clinical outcomes such as prolonged ICU stays and increased mortality. Understanding the factors contributing to thrombocytopenia is essential for risk assessment and management in intensive care settings.

Data Highlights

Key Findings

• Bleeding is associated with a higher occurrence of thrombocytopenia (OR = 3.49).
• Sepsis significantly increases the likelihood of thrombocytopenia (OR = 2.32).
• Impaired liver function correlates with thrombocytopenia (OR = 1.55).
• A Simplified Acute Physiology Score (SAPS) < 20 shows a modest association with thrombocytopenia (OR = 1.09).

Clinical Implications

Clinicians should be aware of the associations between bleeding, sepsis, and liver function impairment with thrombocytopenia in critically ill patients. Monitoring these factors may facilitate early identification of patients at risk for adverse outcomes.

Conclusion

The study highlights critical factors associated with thrombocytopenia in ICU settings.

Related Resources & Content

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9. Risk factors for thrombocytopenia in adult patients with sepsis: A systematic review and meta-analysis - PubMed
10. Re-evaluating the association between thrombocytopenia and bleeding in extracorporeal membrane oxygenation (ECMO) - Albert Leng, Hannah Rando, Manuj Shah, Armaan Akbar, Benjamin Shou, Andrew Kalra, Sung-Min Cho, Glenn J. R. Whitman, , On behalf of HERALD Investigators, On behalf of HERALD Investigators, 2025
11. Transfusion of Fresh Frozen Plasma and Platelets in Critically Ill Adults | Critical Care - American College of Chest Physicians