Case Report: Asymmetric recovery unmasking watershed infarction in a patient with ICU-acquired weakness - Report - MDSpire

Case Report: Asymmetric recovery unmasking watershed infarction in a patient with ICU-acquired weakness

  • By

  • Bingqing Zhao

  • Meng Yu

  • Peining Zhou

  • Fan Li

  • Junfang Huang

  • Jing Ma

  • Zhaoxia Wang

  • June 24, 2026

  • 0 min

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Clinical Report: Uneven Recovery Revealing Watershed Infarction in ICU Patient

Overview

This case study presents a 59-year-old female who developed profound muscle weakness following ICU admission for severe pneumonia and septic shock. Subsequent imaging revealed watershed infarctions.

Background

ICU-acquired weakness (ICUAW) is a common complication in critically ill patients, often leading to significant physical impairment and challenges in weaning from mechanical ventilation. The condition can present with atypical symptoms, complicating diagnosis and management.

Data Highlights

No numerical data or trial data provided in the article.

Key Findings

  • A 59-year-old female developed profound muscle weakness post-ICU admission for pneumonia and septic shock.
  • Initial diagnosis of ICUAW was supported by electrophysiological studies and muscle biopsy.
  • Asymmetrical motor recovery was observed, with persistent left-sided deficits despite negative cranial CT.
  • Cranial MRI revealed fresh watershed infarctions in the right hemisphere.
  • A tailored rehabilitation strategy led to significant functional improvement, with full recovery at 2-year follow-up.

Clinical Implications

This case underscores the importance of thorough neurological evaluation in patients with ICUAW, especially when recovery patterns are atypical. A multimodal approach to rehabilitation may enhance recovery outcomes in complex ICU patients.

Conclusion

The findings from this case highlight the need for vigilance in diagnosing and managing ICUAW, particularly when neurological complications may be present. A comprehensive rehabilitation strategy is essential for optimal recovery.

Related Resources & Content

  1. Critical Care (Springer), 2026 -- Efficacy of suspension-based lower-limb rehabilitation device in enhancing lower limb function among patients with ICU-acquired weakness: a self-controlled randomized clinical trial
  2. conexiant, 2025 -- Early ICU Rehab Backed, With Caveats
  3. Critical Care (Springer), 2025 -- Resistance training and β-hydroxy-β-methylbutyrate for functional recovery in critical illness: a multicenter 2 × 2 factorial randomized trial
  4. Intensive Care Medicine, 2017 -- Muscle Atrophy in Upper and Lower Limbs of Critically Ill Patients: Findings from an Observational Study Using Ultrasonography
  5. ICU-acquired weakness - Knowledge @ AMBOSS
  6. Australian clinical practice guideline for physical rehabilitation and mobilisation in adult intensive care units - PubMed
  7. Diagnosis and treatment of Watershed strokes: a narrative review - PMC
  8. ICU-acquired weakness - Knowledge @ AMBOSS
  9. Australian clinical practice guideline for physical rehabilitation and mobilisation in adult intensive care units - PubMed
  10. Diagnosis and treatment of Watershed strokes: a narrative review - PMC

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