Uncommon Presentation of Onychomycosis Caused by Aspergillus niger in a Healthy Adult: A Case of Non-Dermatophyte Mold Infection - Report - MDSpire

Uncommon Presentation of Onychomycosis Caused by Aspergillus niger in a Healthy Adult: A Case of Non-Dermatophyte Mold Infection

  • By

  • Sugat A. Jawade

  • Nandkishor J. Bankar

  • Sudhir P. Singh

  • Sabiha T. Quazi

  • Mayur S. Dudhe

  • Rutwik Khandeshe

  • January 22, 2026

  • 0 min

Share

Clinical Report: Uncommon Presentation of Onychomycosis Caused by Aspergillus niger

Overview

This report details a rare case of onychomycosis caused by Aspergillus niger in an immunocompetent adult male, highlighting the diagnostic challenges associated with non-dermatophyte mold infections. The findings underscore the importance of accurate mycological investigations in cases of atypical nail discoloration.

Background

Onychomycosis is a prevalent fungal infection of the nails, with non-dermatophyte molds (NDMs) increasingly recognized as significant pathogens. These infections can present with atypical features, leading to misdiagnosis and delayed treatment. Understanding the role of NDMs is crucial for effective management, especially in humid climates where their prevalence is higher.

Data Highlights

No numerical data or trial data available in the article.

Key Findings

  • An immunocompetent male presented with a 4-month history of brown discoloration of the right index fingernail.
  • Direct microscopy revealed dichotomous septate hyphae, indicative of a mold infection.
  • Cultures confirmed the presence of Aspergillus niger, ruling out dermatophytes.
  • Histopathological examination was not performed, which is a noted limitation of the case.
  • NDM infections may present without typical signs of inflammation, complicating diagnosis.

Clinical Implications

Clinicians should maintain a high index of suspicion for NDMs in cases of atypical onychomycosis, particularly in humid environments. Accurate diagnosis necessitates a combination of clinical evaluation and mycological testing to ensure appropriate treatment.

Conclusion

This case highlights the need for awareness of non-dermatophyte molds as potential primary pathogens in onychomycosis. Early recognition and appropriate diagnostic measures are essential for effective management.

References

  1. Author(s)/Org, Source, Year -- Title
  2. Open Forum Infectious Diseases, Case Study of Primary Cutaneous Invasive Aspergillosis in a Neutropenic Patient After Finger Trauma
  3. Open Forum Infectious Diseases, Pulmonary Infections Associated with Trametes elegans and Peniophora incarnata
  4. Open Forum Infectious Diseases, Unmasking Lomentospora prolificans: A Case Study of Fungemia with Diagnostic Challenges
  5. Onychomycosis | Johns Hopkins ABX Guide
  6. Fingernail Onychomycosis: A Laboratory-Based Retrospective Study with Species Profiling and Antifungal Susceptibility of Yeasts - PMC
  7. Journal of Dermatological Treatment
  8. Onychomycosis | Johns Hopkins ABX Guide
  9. Fingernail Onychomycosis: A Laboratory-Based Retrospective Study with Species Profiling and Antifungal Susceptibility of Yeasts - PMC
  10. Journal of Dermatological Treatment

Original Source(s)

Related Content