Long-term efficacy of neural circuit blockade for treating blepharospasm: a retrospective case series study - Report - MDSpire

Long-term efficacy of neural circuit blockade for treating blepharospasm: a retrospective case series study

  • By

  • Gang Liu

  • Qiangying Guo

  • Jie Xiang

  • Zhen Xu

  • Suying Chen

  • Yanling Xue

  • Zhitao Liu

  • Huixia Jin

  • Shangyi Yu

  • Ting Jiao

  • Xia Chen

  • Zhenzhen Liu

  • Xiangying Xi

  • Yanhong Li

  • Lili Shang

  • Jiao Du

  • Xianzhong Liu

  • Shihui Wei

  • June 24, 2026

  • 0 min

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Clinical Report: Long-term effectiveness of neural circuit blockade in blepharospasm

Overview

This study evaluates the long-term efficacy of neural circuit blockade (NCB) in managing blepharospasm. A retrospective analysis of 570 patients showed that NCB led to a reduction in dystonia scores.

Background

Blepharospasm is a debilitating form of focal dystonia that can result in functional blindness and severely impacts quality of life. Current treatment options, including botulinum toxin injections and surgical interventions, often yield unsatisfactory results.

Data Highlights

MeasurePreoperativePostoperative
Shorr grading scaleGrade 4: 97.9%Grade 0: 87.5%
BFMDRS-M (eye)8.00.0
BFMDRS-M (mouth)3.00.0
BFMDRS-M (speech/swallowing)3.02.0
BFMDRS-M (neck)3.01.5
Total BFMDRS-M8.00.0

Key Findings

  • 97.9% of patients were grade 4 on the Shorr grading scale preoperatively.
  • 87.5% of patients achieved complete remission (grade 0) postoperatively.
  • Significant reductions in BFMDRS-M scores were observed across all measured areas.
  • NCB did not result in severe local or systemic complications, such as facial paralysis.
  • The median follow-up period for patients was 51 months.

Clinical Implications

Clinicians should consider NCB as a treatment option for patients with blepharospasm.

Conclusion

Neural circuit blockade demonstrates efficacy in alleviating blepharospasm symptoms.

Related Resources & Content

  1. Ophthalmology Management, 2006 -- Blepharospasm: The Condition and Treatment Options
  2. Intraoperative Assessment of Lateral Spread Response in Upper Orbicularis Oculi and Mandibular Muscles Following Botulinum Toxin Therapy in Hemifacial Spasm Patients
  3. Glaucoma Physician, 2022 -- Tips and Tricks for Bleb Needling
  4. Blepharospasm | National Eye Institute
  5. Blepharospasm: Definition, Causes & Treatment Options | Cleveland Clinic
  6. Frontiers in Medicine — Analysis of the Application Effect of an Automated Eye Position Fixation Training Device in Patients Undergoing Pterygium Surgery: A Two-Year Follow-Up Randomized Controlled Trial
  7. Blepharospasm | National Eye Institute
  8. https://miyazaki-u.repo.nii.ac.jp/record/2002403/files/toxins-18-00109-v2.pdf
  9. Blepharospasm: Definition, Causes & Treatment Options

Original Source(s)

Long-term efficacy of neural circuit blockade for treating blepharospasm: a retrospective case series study

  • by Gang Liu, Qiangying Guo, Jie Xiang, Zhen Xu, Suying Chen, Yanling Xue, Zhitao Liu, Huixia Jin, Shangyi Yu, Ting Jiao, Xia Chen, Zhenzhen Liu, Xiangying Xi, Yanhong Li, Lili Shang, Jiao Du, Xianzhong Liu, Shihui Wei

  • June 24, 2026

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