Atypical congenital toxoplasmosis presenting with neonatal jaundice and central nervous system involvement: a case report and therapeutic challenges to limited access to first-line anti-toxoplasma medications - Report - MDSpire
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Atypical congenital toxoplasmosis presenting with neonatal jaundice and central nervous system involvement: a case report and therapeutic challenges to limited access to first-line anti-toxoplasma medications
Clinical Report: Unusual Presentation of Congenital Toxoplasmosis
Overview
This case study presents a neonate with congenital toxoplasmosis who initially exhibited jaundice and was later diagnosed with significant neurological and ocular involvement.
Background
Congenital toxoplasmosis (CT) is a significant parasitic infection that can lead to severe neurological and ocular complications in neonates. The classic presentation includes a triad of symptoms, but isolated jaundice can delay diagnosis.
Data Highlights
Case details include: - 9-day-old male infant with jaundice - Positive Toxoplasma gondii IgM and IgG - Detection of T. gondii DNA via mNGS - CSF analysis showing pleocytosis and elevated protein - MRI revealing cerebral edema and punctate hemorrhages
Key Findings
Congenital toxoplasmosis can present with isolated neonatal jaundice.
Systematic evaluation is essential for early disease characterization.
Standard therapy with pyrimethamine, sulfadiazine, and folinic acid is recommended when available.
Long-term follow-up is necessary to monitor for potential sequelae.
Clinical Implications
Clinicians should consider congenital toxoplasmosis in neonates presenting with unexplained jaundice. Comprehensive evaluation, including neuroimaging and auditory testing, is critical for effective management.
Conclusion
This case highlights the importance of recognizing atypical presentations of congenital toxoplasmosis.
