Clinical Report: Link Between Serum Uric Acid to HDL Cholesterol Ratio and In-Hospital Mortality in Acute Kidney Injury Patients

Overview

This study investigates the association between the uric acid to HDL cholesterol ratio (UHR) and in-hospital mortality in patients with acute kidney injury (AKI).

Background

Acute kidney injury (AKI) is a prevalent condition in hospitalized patients, associated with high morbidity and mortality rates. Identifying reliable prognostic indicators is crucial for improving patient outcomes.

Data Highlights

Key Findings

• UHR is significantly associated with in-hospital mortality in AKI patients.
• Each unit increase in UHR corresponds to a 55% increase in the hazard of in-hospital mortality (HR: 1.55; 95% CI: 1.18-2.01, p=0.002).
• Non-survivors had higher serum creatinine, blood urea nitrogen, and C-reactive protein levels compared to survivors.
• The association between UHR and mortality was stronger in older patients and those with severe renal impairment.

Clinical Implications

The findings suggest that UHR could be utilized as a prognostic tool in clinical settings to identify AKI patients at higher risk of in-hospital mortality. This may assist healthcare providers in making informed decisions regarding patient management and intervention strategies.

Conclusion

UHR is associated with in-hospital mortality in AKI patients.

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14. https://kdigo.org/wp-content/uploads/2024/03/KDIGO-2024-CKD-Guideline.pdf