Utility of prenatal ultrasound in diagnosis and prognosis of aortic arch obstruction: a 10-year single-center retrospective study - Report - MDSpire

Utility of prenatal ultrasound in diagnosis and prognosis of aortic arch obstruction: a 10-year single-center retrospective study

  • By

  • He Li

  • Jinwen Chen

  • Wen Ling

  • Qiumei Wu

  • Biying Huang

  • Guorong Lyu

  • Caihong Jiang

  • Zongjie Weng

  • July 3, 2026

  • 0 min

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Clinical Report: Evaluating the Role of Prenatal Ultrasound in Aortic Arch Obstruction

Overview

This study evaluates the diagnostic accuracy and outcomes of prenatal ultrasound in identifying aortic arch obstruction, focusing on differentiating interrupted aortic arch (IAA) from coarctation of the aorta (CoA). The findings indicate a high prenatal diagnostic accuracy of 90.28%.

Background

Aortic arch obstruction, including IAA and CoA, is a significant congenital heart defect that can lead to severe clinical outcomes if not diagnosed early. Accurate prenatal diagnosis is crucial for risk stratification and management planning.

Data Highlights

ConditionPercentage
Interrupted Aortic Arch Type A22.22%
Interrupted Aortic Arch Type B20.83%
Interrupted Aortic Arch Type C6.94%
Coarctation of the Aorta50.00%

Key Findings

  • Overall prenatal diagnostic accuracy for aortic arch obstruction was 90.28%.
  • IAA cases exhibited significantly smaller aortic valve annulus Z-scores and ascending aorta Z-scores compared to CoA.
  • 88.89% of cases had associated intracardiac malformations, with a higher prevalence in IAA.
  • IAA was linked to more severe hypoxia and cyanosis, resulting in lower postoperative survival rates.
  • CoA cases demonstrated more favorable early outcomes compared to IAA.

Clinical Implications

Prenatal echocardiography is essential for the early detection of aortic arch obstruction and for differentiating between IAA and CoA.

Conclusion

The study highlights the role of prenatal echocardiography in identifying aortic arch obstruction and differentiating between its types.

Related Resources & Content

  1. Pediatric Cardiology, 2025 -- Assessment of Tracheal Structure in Double Aortic Arch for Predicting Symptoms and Surgical Necessity Postnatally
  2. Pediatric Cardiology, 2015 -- Outcomes of Single-Stage Surgical Intervention for Aortic Arch Obstruction in Patients with Transposition of the Great Arteries: A Decadal Review
  3. Pediatric Cardiology, 2020 -- Prenatal Echocardiographic Measurements: Key Indicators for Postnatal Coarctation of the Aorta
  4. ISUOG Practice Guidelines (updated): fetal cardiac screening - PubMed
  5. Pediatric Cardiology — Fetal Myocardial Deformation in Relation to Ventricular Geometry, Preload, and Afterload in Cases of Suspected Aortic Coarctation
  6. ISUOG Practice Guidelines (updated): fetal cardiac screening - PubMed
  7. Hemodynamic and developmental biomarkers enhance prenatal coarctation prediction: a validated multiparametric ultrasound model | Archives of Gynecology and Obstetrics | Springer Nature Link
  8. Prenatal Ultrasound Diagnosis and Genetic Analysis of Interrupted Aortic Arch - PubMed

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