Psychoneuroimmunological changes in adults with obesity receiving chiropractic care: a single-arm pilot trial - Report - MDSpire

Psychoneuroimmunological changes in adults with obesity receiving chiropractic care: a single-arm pilot trial

  • By

  • Tyson M. Perez

  • Margaret Sliwka

  • Daekiara Smith-Ireland

  • Amber Jackson

  • Stephanie Sullivan

  • July 17, 2026

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Clinical Report: Psychoneuroimmunological Effects in Obese Adults Undergoing Chiropractic Treatment

Overview

This pilot study assessed the feasibility of a psychoneuroimmunology-focused assessment in obese adults receiving chiropractic care.

Background

Obesity is a growing global health concern, with significant associations to psychoneuroimmunological dysfunction. This study aims to explore the feasibility of integrating PNI assessments with chiropractic care for adults with obesity.

Data Highlights

The study enrolled 18 participants (12 females; mean age 48.7 ± 9.0 years) who underwent 6 weeks of chiropractic care. Assessments were conducted at baseline, 2 weeks, and 6 weeks.

Key Findings

  • The study design was deemed feasible with necessary revisions.
  • Self-reported improvements in autonomic nervous system functioning were noted.
  • Perceived stress levels showed significant within-group improvements.
  • No causal inferences can be drawn from the results.

Clinical Implications

The findings suggest that chiropractic care may influence PNI-related outcomes in obese adults. Further research is warranted to establish the efficacy of this approach.

Conclusion

This pilot study highlights the potential for integrating PNI assessments in chiropractic care for obesity, paving the way for future research in this area.

Related Resources & Content

  1. Perez et al., Frontiers in Medicine, 2023 -- Psychoneuroimmunological Effects in Obese Adults Undergoing Chiropractic Treatment: A Pilot Study
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  4. Dermatology and Therapy — Efficacy and Safety of Tildrakizumab for Treatment of Moderate-to-Severe Scalp Psoriasis in Patients with Obesity Over 52 Weeks
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  7. Clinical Evidence of Wearable-Derived Heart Rate Variability for Detecting Systemic Inflammation: A Systematic Review - PubMed

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