Efficacy and safety of tumor treating fields (TTF) combined with chemotherapy versus chemotherapy only in the treatment of glioblastoma: a systematic review and meta-analysis - Report - MDSpire

Efficacy and safety of tumor treating fields (TTF) combined with chemotherapy versus chemotherapy only in the treatment of glioblastoma: a systematic review and meta-analysis

  • By

  • Naibijiang Abuliezi

  • Yihan Sun

  • Jiale Zhao

  • Xinge Qu

  • Yanyan Wu

  • Tiantian Liao

  • Gulinuer Kuerban

  • Xiaoyi Dun

  • Qinfen Wu

  • May 8, 2026

  • 0 min

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Clinical Report: Assessment of Tumor Treating Fields in Glioblastoma Therapy

Overview

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Background

Glioblastoma (GBM) is the most common and aggressive primary brain tumor, with a poor prognosis despite standard treatments. The need for more effective therapies is critical, as current multimodal approaches yield limited survival benefits. Tumor treating fields (TTF) represent a novel treatment modality that may enhance outcomes for GBM patients.

Data Highlights

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Key Findings

{'add': 'Details on subgroup analyses.'}

Clinical Implications

{'add': 'Limitations or considerations for clinicians.'}

Conclusion

{'add': 'Mention the need for further research.'}

Related Resources & Content

  1. Journal of Neuro-Oncology, 2023 -- Impact of Tumor Treating Fields (TTFields) Therapy on Survival Outcomes in Newly Diagnosed Glioblastoma: A Comprehensive Review and Meta-Analysis
  2. The ASCO Post, 2017 -- ‘Out-of-the-Box’ Approach Plus Temozolomide Extends Survival in Glioblastoma
  3. The ASCO Post, 2018 -- Does Treatment With Tumor-Treating Fields Plus Temozolomide Influence Quality of Life in Patients With Newly Diagnosed Glioblastoma?
  4. NCCN Clinical Practice Guidelines in Oncology -- Glioblastoma
  5. Comparison of Radiotherapy and Bevacizumab-Enhanced Radiotherapy for Managing Recurrent High-Grade Gliomas: A Systematic Review
  6. Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma
  7. Frontiers | Efficacy and safety of tumor treating fields (TTF) combined with chemotherapy versus chemotherapy only in the treatment of glioblastoma
  8. ) ® NCCN Clinical Practice Guidelines in Oncology

Original Source(s)

Efficacy and safety of tumor treating fields (TTF) combined with chemotherapy versus chemotherapy only in the treatment of glioblastoma: a systematic review and meta-analysis

  • by Naibijiang Abuliezi, Yihan Sun, Jiale Zhao, Xinge Qu, Yanyan Wu, Tiantian Liao, Gulinuer Kuerban, Xiaoyi Dun, Qinfen Wu

  • May 8, 2026

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