Role of psychological resilience and psychological distress in linking fear of disease progression to quality of life in chronic heart failure: a cross-sectional serial mediation analysis - Report - MDSpire

Role of psychological resilience and psychological distress in linking fear of disease progression to quality of life in chronic heart failure: a cross-sectional serial mediation analysis

  • By

  • Hong Ding

  • Xiaoxia Fang

  • Shixun Li

  • Liyun Miao

  • Xiao Wu

  • May 25, 2026

  • 0 min

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Influence of Psychological Resilience and Distress on QoL in CHF

Overview

This study investigates the mediation effects of psychological resilience and distress on the relationship between fear of disease progression (FoP) and quality of life (QoL) in chronic heart failure (CHF) patients. Findings indicate that both psychological factors significantly mediate this relationship, highlighting the importance of addressing psychological health in CHF management.

Background

Chronic heart failure (CHF) is associated with significant morbidity and reduced quality of life. Fear of disease progression (FoP) is prevalent among CHF patients and can negatively impact treatment adherence and emotional well-being. Understanding the psychological factors that mediate the relationship between FoP and QoL is crucial for improving patient outcomes.

Data Highlights

MeasureMean Score ± SD
Fear of Progression Questionnaire (FoP-Q)43.60 ± 8.32
Connor–Davidson Resilience Scale (CD-RISC)52.71 ± 14.28
Depression Anxiety Stress Scales-21 (DASS-21)44.29 ± 10.68
MLHFQ48.63 ± 10.85

Key Findings

  • FoP was negatively correlated with psychological resilience (r = −0.775).
  • FoP was positively correlated with psychological distress and MLHFQ scores (r = 0.868 and 0.773, respectively).
  • Psychological resilience was negatively correlated with psychological distress and MLHFQ scores (r = −0.728 and −0.744, respectively).
  • The direct effect of FoP on QoL was significant (effect = 0.629, 41.14%).
  • Three indirect pathways were identified: via psychological resilience alone, psychological distress alone, and a serial pathway from resilience to distress.

Clinical Implications

Healthcare providers should assess psychological resilience and distress in CHF patients to enhance their quality of life. Interventions aimed at improving psychological resilience and reducing distress may mitigate the negative effects of fear of disease progression.

Conclusion

The study underscores the importance of psychological factors in chronic heart failure management, suggesting that addressing these aspects can improve patient quality of life.

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