The effect of rehabilitation training based on brain-computer interface on limb function in stroke patients: a systematic review and meta-analyses - Report - MDSpire

The effect of rehabilitation training based on brain-computer interface on limb function in stroke patients: a systematic review and meta-analyses

  • By

  • Ziqiu Zheng

  • Changyue Zhang

  • Mengjiao Lv

  • Chunting Qian

  • Ge Gao

  • Saisai Wang

  • Rujing Zhu

  • Jing Yang

  • Chengwei Zhang

  • Haiyan Xu

  • July 1, 2026

  • 0 min

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Clinical Report: Impact of BCI Rehabilitation on Limb Function Recovery in Stroke Patients

Overview

This systematic review and meta-analysis evaluated the efficacy of brain-computer interface (BCI) rehabilitation on limb function recovery in stroke patients. The findings indicate improvements in both upper and lower limb function compared to control groups, as measured by the Fugl-Meyer Assessment.

Background

Stroke is a leading cause of adult disability and poses significant challenges in rehabilitation due to high rates of motor dysfunction. Traditional rehabilitation methods have limitations, prompting the exploration of innovative approaches like BCI technology.

Data Highlights

AssessmentWeighted Mean Difference (WMD)95% Confidence Interval (CI)p-value
FMA-UE3.50(2.09, 4.90)<0.001
FMA-LE2.59(1.94, 3.23)<0.001

Key Findings

  • BCI rehabilitation improved upper limb function as measured by FMA-UE.
  • BCI rehabilitation led to improvements in lower limb function as measured by FMA-LE.
  • A total of 27 randomized controlled trials (RCTs) were included in the analysis.
  • Motor dysfunction post-stroke affects 60-80% of patients.

Clinical Implications

The findings indicate that BCI-based rehabilitation may improve limb function in stroke patients.

Conclusion

BCI-based rehabilitation demonstrates potential in improving limb function recovery in stroke patients.

Related Resources & Content

  1. Frontiers in Neurology, 2026 -- The effect of non-invasive brain stimulation combined with motor imagery on upper limb motor function and activities of daily living in stroke patients: A systematic review and Meta-analysis
  2. Frontiers in Neurology, 2026 -- Advancing stroke rehabilitation: the potential and challenges of closed-loop brain-computer interface technology
  3. Frontiers in Neurology, 2026 -- Effects of Non-Invasive Neural Stimulation Modalities on Upper Limb Function in Subacute Stroke: A Systematic Review and Meta-Analysis
  4. Frontiers in Medicine, 2026 -- Enhancing motor function after stroke: a systematic review and meta-analysis of bioelectrical feedback interventions
  5. European Stroke Journal, 2025 -- Clinical guidelines and consensus on stroke rehabilitation
  6. Frontiers, 2025 -- The ReHand-BCI trial: a randomized controlled trial of a brain-computer interface for upper extremity stroke neurorehabilitation
  7. https://academic.oup.com/esj/article/10/4/1160/8377197
  8. Frontiers | The ReHand-BCI trial: a randomized controlled trial of a brain-computer interface for upper extremity stroke neurorehabilitation
  9. Efficacy of brain-computer interface training with motor imagery-contingent feedback in improving upper limb function and neuroplasticity among persons with chronic stroke: a double-blinded, parallel-group, randomized controlled trial | Journal of NeuroEngineering and Rehabilitation | Springer Nature Link
  10. https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1643536/pdf

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