Prognostic Significance of the TAPSE/PASP Ratio in Severe Mitral Regurgitation Patients

Overview

This study investigates the prevalence of right ventricular to pulmonary artery (RV-PA) uncoupling in patients undergoing transcatheter edge-to-edge mitral valve repair (M-TEER) and its association with long-term survival.

Background

Mitral valve regurgitation (MR) is a common valvular heart disease, particularly in patients over 75 years. Transcatheter edge-to-edge mitral valve repair (M-TEER) has emerged as a viable treatment option for high-risk patients who are not candidates for surgical repair.

Data Highlights

No numerical data or trial data was provided in the source material.

Key Findings

• The study assessed the TAPSE/D-PASP ratio as a measure of RV-PA coupling in patients undergoing M-TEER.
• RV-PA uncoupling was defined as a TAPSE/D-PASP ratio < 0.37 mm/mmHg.
• The median follow-up period for the cohort was 499 ± 832 days.
• Loss to follow-up was observed in 5.1% of patients, with no significant difference between those with and without RV-PA uncoupling.
• Patients with RV-PA uncoupling showed a trend towards a reduced follow-up period compared to those without.

Clinical Implications

The TAPSE/D-PASP ratio may serve as a useful noninvasive marker for assessing long-term prognosis in patients undergoing M-TEER. Clinicians should consider this ratio when evaluating patients for potential interventions.

Conclusion

The study underscores the importance of RV-PA coupling in predicting outcomes for patients with severe MR undergoing M-TEER. Further research is needed to validate these findings in larger cohorts.

Related Resources & Content

1. Clinical Research in Cardiology, 2025 -- Echocardiographic and Invasive RV-PA Coupling as Predictors of Mortality Following Edge-to-Edge Repair for Degenerative Mitral Regurgitation: Findings from a Single-Center Observational Study
2. Clinical Research in Cardiology, 2020 -- Comparative Analysis of PASCAL and MitraClip-XTR Edge-to-Edge Devices for Managing Tricuspid Regurgitation: A Propensity-Matched Study
3. Clinical Research in Cardiology, 2023 -- Enhancing the Precision of Right Ventricular to Pulmonary Artery Coupling in Patients Receiving Transcatheter Treatment for Tricuspid Valve Disorders
4. Clinical Research in Cardiology, 2021 -- Comparison of PASCAL Mitral Valve Repair System and MitraClip in Treating Complex Primary Mitral Regurgitation with Transcatheter Edge-to-Edge Techniques
5. 2025 ESC/EACTS Guidelines for the management of valvular heart disease
6. New England Journal of Medicine, 2024 -- Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation
7. American Society of Echocardiography, 2025 -- Guidelines for the Echocardiographic Assessment of the Right Heart in Adults and Special Considerations in Pulmonary Hypertension
8. 2025 ESC/EACTS Guidelines for the management of valvular heart disease
9. Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation | New England Journal of Medicine
10. Guidelines for the Echocardiographic Assessment of the Right Heart in Adults and Special Considerations in Pulmonary Hypertension: Recommendations from the American Society of Echocardiography