The Role of IFI27 in Modulating Regulatory T Cell Activity Contributes to Lung Injury in Sepsis Through IL-10/STAT3 Pathway - Report - MDSpire

The Role of IFI27 in Modulating Regulatory T Cell Activity Contributes to Lung Injury in Sepsis Through IL-10/STAT3 Pathway

  • By

  • Juan Li

  • Yingying Huang

  • Chaoping Ma

  • Guoxiang Liu

  • Caiting Chu

  • Jiameng Chen

  • Huiqi Wang

  • Jiawei Ye

  • Min Jiao

  • Yiran Guo

  • Jiyuan Zhang

  • Yuxin Leng

  • Chengjin Gao

  • April 22, 2026

  • 0 min

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Clinical Report: The Role of IFI27 in Modulating Regulatory T Cell Activity

Overview

This study investigates the role of IFI27 in regulatory T cell modulation during sepsis and its contribution to lung injury. Elevated IFI27 levels correlate with sepsis severity and inhibit Treg function, exacerbating lung epithelial ferroptosis through the IL-10/STAT3 pathway.

Background

Sepsis is a critical condition that leads to multiple organ dysfunction, particularly affecting the lungs. Regulatory T cells (Tregs) are essential for maintaining immune balance and protecting lung epithelial cells during sepsis. Understanding the mechanisms by which IFI27 influences Treg activity could provide insights into potential therapeutic targets for sepsis-induced lung injury.

Data Highlights

ParameterFindings
Plasma IFI27 levelsPositively correlated with sepsis severity
IFI27 expression in septic miceSignificantly increased
Treg abundanceReduced due to elevated IFI27
IL-10 secretionInhibited by increased IFI27
Lipid peroxidation levelsIncreased with IFI27 elevation

Key Findings

  • IFI27 levels correlate positively with the severity of sepsis.
  • Increased IFI27 expression in septic mice leads to reduced Treg abundance.
  • Elevated IFI27 inhibits IL-10 secretion from Tregs.
  • IFI27 elevation exacerbates ferroptosis in lung epithelial cells.
  • IFI27 suppresses the IL-10/STAT3 signaling pathway, worsening lung injury.

Clinical Implications

Monitoring IFI27 levels may serve as a prognostic indicator in sepsis patients. Therapeutic strategies aimed at modulating IFI27 activity could enhance Treg function and mitigate lung injury in sepsis.

Conclusion

IFI27 plays a significant role in sepsis-related lung injury by modulating Treg activity and enhancing ferroptosis. Targeting the IFI27 pathway may offer new therapeutic avenues for improving outcomes in sepsis.

References

  1. Frontiers | IFI27-Mediated Regulation of Regulatory T cells Aggravates Lung Injury in Sepsis via IL-10/STAT3 signaling
  2. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026 - PubMed
  3. Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial | Allergy and Clinical Immunology | JAMA | JAMA Network
  4. Intensive Care Medicine — 21st Annual Congress of the European Society of Intensive Care Medicine
  5. Journal of Gastroenterology — Significance of the IL-22 Pathway in Inflammatory Bowel Disease
  6. The ASCO Post — Is IFITM3 a Driver of Immunotherapy Response in SCLC?
  7. The Journal of Infectious Diseases — FGF8 Protects Against Polymicrobial Sepsis by Enhancing the Host's Anti-infective Immunity
  8. Intensive Care Medicine — 21st Annual Congress of the European Society of Intensive Care Medicine
  9. Journal of Gastroenterology — Significance of the IL-22 Pathway in Inflammatory Bowel Disease
  10. The ASCO Post — Is IFITM3 a Driver of Immunotherapy Response in SCLC?
  11. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026 - PubMed
  12. Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial | Allergy and Clinical Immunology | JAMA | JAMA Network
  13. Frontiers | IFI27-Mediated Regulation of Regulatory T cells Aggravates Lung Injury in Sepsis via IL-10/STAT3 signaling

Original Source(s)

The Role of IFI27 in Modulating Regulatory T Cell Activity Contributes to Lung Injury in Sepsis Through IL-10/STAT3 Pathway

  • by Juan Li, Yingying Huang, Chaoping Ma, Guoxiang Liu, Caiting Chu, Jiameng Chen, Huiqi Wang, Jiawei Ye, Min Jiao, Yiran Guo, Jiyuan Zhang, Yuxin Leng, Chengjin Gao

  • April 22, 2026

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