Clinical Report: Primary Synovial Sarcoma Originating in the Kidney
Overview
This report details a case of primary renal synovial sarcoma in a 53-year-old male, highlighting the diagnostic challenges and treatment outcomes. The patient underwent radical nephrectomy followed by chemotherapy, with no evidence of recurrence during follow-up.
Background
Primary renal synovial sarcoma is an exceptionally rare malignancy, accounting for less than 2% of renal cancers. Its clinical presentation often mimics that of more common renal cell carcinoma, necessitating advanced diagnostic techniques for accurate identification. Understanding this rare entity is crucial for timely intervention and management.
Data Highlights
Parameter
Value
Left Renal Mass Size
13.3 cm × 11.6 cm
Ki-67 Proliferation Index
30%
Postoperative Follow-up
No recurrence or metastasis
Key Findings
Patient presented with intermittent left flank and abdominal pain.
Imaging revealed a large, heterogeneously enhancing renal mass.
Pathological diagnosis confirmed synovial sarcoma via immunohistochemistry and genetic testing.
Postoperative chemotherapy included epirubicin and ifosfamide.
No evidence of metastasis or recurrence was observed during follow-up.
Clinical Implications
Clinicians should consider primary renal synovial sarcoma in differential diagnoses for renal masses, especially when imaging suggests malignancy. Early diagnosis and a multidisciplinary approach to treatment, including radical nephrectomy and adjuvant chemotherapy, are essential for improving patient outcomes.
Conclusion
This case underscores the importance of recognizing primary renal synovial sarcoma as a rare but significant renal malignancy, warranting specific diagnostic and therapeutic strategies.
