Effects of dexmedetomidine nasal spray on perioperative anxiety and quality of postoperative recovery in patients undergoing modified radical mastectomy for breast cancer - Report - MDSpire

Effects of dexmedetomidine nasal spray on perioperative anxiety and quality of postoperative recovery in patients undergoing modified radical mastectomy for breast cancer

  • By

  • Qi Han

  • Zichao Li

  • Hongyi Xiao

  • Fanceng Ji

  • Chunhui Zheng

  • Qinglan Li

  • June 15, 2026

  • 0 min

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Impact of Intranasal Dexmedetomidine on Perioperative Anxiety and Recovery

Overview

This study evaluates the effects of preoperative intranasal dexmedetomidine on perioperative anxiety and postoperative recovery in breast cancer patients undergoing modified radical mastectomy.

Background

Breast cancer is the most commonly diagnosed malignancy among women, with surgery being a primary treatment modality. Perioperative anxiety is prevalent in this population.

Data Highlights

OutcomeGroup D (Dexmedetomidine)Group C (Control)P-value
PAS-7 Score (30 min)9.71 ± 2.0712.44 ± 1.98< 0.001
QoR-15 Score (24 h)120.11 ± 6.90111.27 ± 7.14< 0.001
QoR-15 Score (48 h)127.04 ± 6.39123.20 ± 6.370.005
Time to Emergence8.36 ± 2.796.36 ± 2.830.001

Key Findings

  • Preoperative intranasal dexmedetomidine significantly reduced PAS-7 scores compared to control.
  • QoR-15 scores were significantly higher at both 24 and 48 hours postoperatively in the dexmedetomidine group.
  • No significant differences in AIS scores or intraoperative hemodynamic variables were observed.
  • Time to emergence was significantly longer in the dexmedetomidine group.
  • Baseline characteristics were comparable between the two groups.

Clinical Implications

Findings suggest that preoperative intranasal dexmedetomidine is associated with changes in anxiety and recovery metrics.

Conclusion

Preoperative intranasal dexmedetomidine is associated with changes in anxiety and recovery quality in breast cancer patients.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. BMC Psychiatry (Springer) -- Impact of Low-Dose Esketamine on Anxiety and Depression in Post-Surgical Breast Cancer Patients: A Double-Blind, Randomized Controlled Trial
  3. Frontiers in Medicine -- Effects of dexmedetomidine nasal spray combined with propofol for deep sedation in patients undergoing endoscopic retrograde cholangiopancreatography: a prospective randomized study
  4. 2025 American Society of Anesthesiologists Practice Advisory for Perioperative Care of Older Adults Scheduled for Inpatient Surgery - PubMed
  5. Frontiers in Medicine — Effect of lidocaine on acute pain after modified radical mastectomy: a secondary analysis of a randomized trial
  6. Implementing ERAS: AORN's Guideline for Enhanced Recovery After Surgery
  7. Preoperative anxiety and its impact on surgical outcomes: A systematic review and meta-analysis
  8. 2025 American Society of Anesthesiologists Practice Advisory for Perioperative Care of Older Adults Scheduled for Inpatient Surgery - PubMed
  9. Enhanced recovery after surgery: overarching themes of the ERAS® Society Guidelines & Consensus Statements for Adult Specialty Surgery | Perioperative Medicine | Full Text
  10. Effectiveness of dexmedetomidine on patient-centred outcomes in surgical patients: a systematic review and Bayesian meta-analysis - ScienceDirect
  11. Recovery quality with regional anesthesia and dexmedetomidine sedation versus general anesthesia for ambulatory breast cancer surgery: A randomized trial - PMC
  12. Effect of different doses of intravenous dexmedetomidine as an adjunct to the serratus anterior plane block in patients undergoing modified radical mastectomy: a randomized controlled trial - PMC
  13. Effect of Dexmedetomidine and Two Different Doses of Esketamine Combined Infusion on the Quality of Recovery in Patients Undergoing Modified Radical Mastectomy for Breast Cancer - A Randomised Controlled Study - PMC
  14. Full article: Preventive Effect of Preoperative Intranasal Dexmedetomidine for Postoperative Delirium in Elderly Patients with Sleep Disorders Undergoing Major Noncardiac Surgery: A Randomized, Triple-Blind, Placebo-Controlled Trial
  15. Effects of Dexmedetomidine Nasal Sprays on Postoperative Sleep Quality in Patients Who Underwent Laparoscopic Gynaecological Surgery: A Single-Centre, Double-Blind, Randomized Controlled Study - PMC
  16. Full article: The Effect of Low-Dose Dexmedetomidine Nasal Spray on Anxiety Levels in Gynaecological Patients on the Day of Surgery: A Randomised Controlled Study

Original Source(s)

Effects of dexmedetomidine nasal spray on perioperative anxiety and quality of postoperative recovery in patients undergoing modified radical mastectomy for breast cancer

  • by Qi Han, Zichao Li, Hongyi Xiao, Fanceng Ji, Chunhui Zheng, Qinglan Li

  • June 15, 2026

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