Elevated triglyceride glucose-body mass index is associated with a higher risk of reduced cumulative live birth and adverse pregnancy outcomes in women undergoing assisted reproductive technology: a retrospective cohort study - Report - MDSpire
Advertisement
Elevated triglyceride glucose-body mass index is associated with a higher risk of reduced cumulative live birth and adverse pregnancy outcomes in women undergoing assisted reproductive technology: a retrospective cohort study
Clinical Report: Elevated TyG-BMI and Adverse Pregnancy Outcomes in ART
Overview
This study examines the association between maternal triglyceride glucose-body mass index (TyG-BMI) and reproductive outcomes in women undergoing assisted reproductive technology (ART).
Background
Infertility affects approximately one in six adults globally. Assisted reproductive technologies (ART) have become essential for treating infertility, yet success rates vary widely. Understanding metabolic factors, such as insulin resistance indicated by TyG-BMI, is crucial.
Data Highlights
Outcome
Adjusted Risk Ratio (aRR)
95% Confidence Interval
Cumulative Live Birth Rate
0.973
0.956–0.991
First-Trimester Miscarriage
1.090
1.002–1.185
Second/Third-Trimester Fetal Loss
1.694
1.481–1.938
Preterm Birth
1.244
1.170–1.323
Macrosomia
2.352
2.060–2.685
Key Findings
A significant linear inverse association exists between TyG-BMI and cumulative live birth rate (P-overall = 0.029).
Women in the highest TyG-BMI tertile (>203) have a lower cumulative live birth rate compared to those in the lowest tertile (≤177).
Higher TyG-BMI is associated with increased risk of first-trimester miscarriage (aRR 1.090).
Increased TyG-BMI correlates with higher risks of second- or third-trimester fetal loss (aRR 1.694).
TyG-BMI is linked to a higher risk of preterm birth (aRR 1.244) and macrosomia (aRR 2.352).
Clinical Implications
Monitoring TyG-BMI may provide valuable insights into the reproductive health of women undergoing ART. Clinicians should consider metabolic assessments as part of the preconception care for women seeking fertility treatments.
Conclusion
Higher maternal TyG-BMI is associated with reduced cumulative live birth rates and increased risks of adverse pregnancy outcomes in women receiving ART.
