COVID-19 Vaccine Effectiveness Among Older Adults - Report - MDSpire

COVID-19 Vaccine Effectiveness Among Older Adults

  • By

  • Charlotte Laniece Delaunay

  • Alberto Mateo-Urdiales

  • Gloria Pérez-Gimeno

  • Karen O’Reilly

  • Marina Uras

  • Annika Erdwiens

  • Ivan Mlinarić

  • Gergő Túri

  • Iván Martínez-Baz

  • Adam Meijer

  • Ana Paula Rodrigues

  • Mihaela Lazăr

  • Neus Latorre-Margalef

  • Héloïse Lucaccioni

  • Nuno Verdasca

  • Antonino Bella

  • Maria Angeles Rafael de la Cruz Lopez

  • Eva Kelly

  • Vincent Enouf

  • Kristin Tolksdorf

  • Simona Puzelli

  • Ana Carmen Ibáñez Pérez

  • Margaret Fitzgerald

  • Shirley Masse

  • Djin-Ye Oh

  • Marlena Kaczmarek

  • Sabrina Bacci

  • Esther Kissling

  • VEBIS Primary Care Vaccine Effectiveness Group

  • Sanja Kurečić Filipović

  • Vesna Višekruna Vučina 

  • Ivana Ferenčak

  • Bernard Kaić

  • Katica Čusek Adamić

  • Mirjana Lana Kosanović Ličina

  • Ivana Mihin Huskić

  • Diana Nonković

  • Morana Tomljenović

  • Caroline Guerrisi

  • Cécile Souty

  • Thierry Blanchon

  • Titouan Launay

  • Alessandra Falchi

  • Marie Chazelle

  • Leïla Renard

  • Marie-Anne Rameix-Welti

  • Danielle Perez-Bercoff

  • Antonin Bal

  • Bruno Lina

  • Ralf Dürrwald

  • Barbara Biere

  • Janine Reiche

  • Marianne Wedde

  • Ute Preuß

  • Irmgard Stroetmann

  • Beatrix Oroszi

  • Viktória Velkey

  • Katalin Krisztalovics

  • Katalin Kristóf

  • Michael Joyce

  • Sara  Piacentini

  • Emanuela Giombini

  • Marzia Facchini

  • Angela Di Martino

  • Massimo Fabiani

  • Benedetta Bellini

  • Patrizio Pezzotti

  • Paola Stefanelli

  • Dirk Eggink

  • Anne Huiberts

  • Rianne van Gageldonk-Lafeber

  • Mariëtte Hooiveld

  • Ausenda Machado

  • Raquel Guiomar

  • João Almeida Santos

  • Licínia Gomes

  • Maria Elena Mihai

  • Alina Ivanciuc

  • Catalina Pascu

  • Sorin Dinu

  • Mihaela Oprea

  • Olivia Timnea

  • Adrian Jidovu

  • Susana Monge

  • Marcos Lozano

  • Francisco Pozo

  • Inmaculada Casas

  • Sonia Vázquez-Morón

  • Carmen Roman-Ortiz

  • Ignacio Campo-Palacio

  • Camino Trobajo-Sanmartín

  • Aitziber Echeverría

  • Itziar Casado

  • Guillermo Ezpeleta

  • Jesús Castilla

  • Ana Navascués

  • María Eugenia Portillo

  • June 15, 2026

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Clinical Report: Effectiveness of COVID-19 Vaccines in Older Populations

Overview

This study evaluates the effectiveness of COVID-19 vaccines in older adults during European vaccination campaigns from September 2025 to January 2026. The overall vaccine effectiveness was found to be 59%, with variations based on time since vaccination. (Verify date range)

Background

Older adults are at increased risk for severe outcomes from COVID-19, making vaccination crucial for this population. Understanding vaccine effectiveness in this age group can inform public health strategies and vaccination campaigns. This study provides insights into the effectiveness of vaccines administered during a specific seasonal campaign in Europe.

Data Highlights

[{'Measure': 'Overall Vaccine Effectiveness', 'Value': '59% (95% CI, 14% to 83%)'}, {'Measure': 'VE at 14 to 41 days', 'Value': '64% (95% CI, 8% to 89%)'}, {'Measure': 'VE at 42 to 83 days', 'Value': '52% (95% CI, -39% to 89%)'}, {'Measure': 'VE within 14 to 59 days', 'Value': '54% (95% CI, 3% to 81%)'}]

Key Findings

['The study included 2046 patients, with 125 cases and 1921 controls.', 'Only 6% of cases were vaccinated compared to 19% of controls.', 'The median age of cases was 72 years, while controls had a median age of 73 years.', '99% of vaccinated patients received the Comirnaty vaccine.', 'Vaccine effectiveness estimates varied by 5% or less in sensitivity analyses, indicating stability in findings.']

Clinical Implications

Healthcare providers should prioritize vaccination in older adults, especially during seasonal campaigns, to enhance protection against COVID-19. Continuous monitoring of vaccine effectiveness is essential to adapt strategies for this vulnerable population, potentially through regular assessments and updated guidelines.

Conclusion

The findings underscore the importance of COVID-19 vaccination in older adults, demonstrating significant effectiveness shortly after vaccination. Ongoing evaluation of vaccine performance will be critical as new variants emerge, ensuring that vaccination strategies remain effective.

Related Resources & Content

  1. Open Forum Infectious Diseases, 2023 -- Comparative Analysis of Immunogenicity and Safety Between Higher-Valent Pneumococcal Conjugate Vaccines and the 13-Valent Vaccine in Elderly Populations: A Systematic Review and Meta-Analysis of Randomized Trials
  2. Frontiers in Immunology, 2026 -- Safety, immunogenicity, and long COVID outcomes following inactivated COVID-19 vaccine boosters in elderly Chinese: a prospective cohort study
  3. JAMA Network Open, 2023 -- Adjuvanted vs High-Dose Influenza Vaccines in Older US Adults: A Cluster Randomized Crossover Study
  4. Drug Safety, 2024 -- Evaluating the Safety of COVID-19 Vaccines in Patients with Compromised Immune Systems: Findings from the European 'Covid Vaccine Monitor' Active Surveillance Study
  5. WHO, 2026 -- Statement on the antigen composition of COVID-19 vaccines
  6. COVID‐19 Vaccine Effectiveness Against Hospitalization in Older Adults, VEBIS Hospital Network, Europe, September 2024–May 2025 - PMC
  7. Efficacy, immunogenicity, and safety of a next-generation mRNA-1283 COVID-19 vaccine compared with the mRNA-1273 vaccine - PubMed
  8. Statement on the antigen composition of COVID-19 vaccines
  9. COVID‐19 Vaccine Effectiveness Against Hospitalization in Older Adults, VEBIS Hospital Network, Europe, September 2024–May 2025 - PMC
  10. Efficacy, immunogenicity, and safety of a next-generation mRNA-1283 COVID-19 vaccine compared with the mRNA-1273 vaccine (NextCOVE): results from a phase 3, randomised, observer-blind, active-controlled trial - PubMed

Original Source(s)

COVID-19 Vaccine Effectiveness Among Older Adults

  • by Charlotte Laniece Delaunay, Alberto Mateo-Urdiales, Gloria Pérez-Gimeno, Karen O’Reilly, Marina Uras, Annika Erdwiens, Ivan Mlinarić, Gergő Túri, Iván Martínez-Baz, Adam Meijer, Ana Paula Rodrigues, Mihaela Lazăr, Neus Latorre-Margalef, Héloïse Lucaccioni, Nuno Verdasca, Antonino Bella, Maria Angeles Rafael de la Cruz Lopez, Eva Kelly, Vincent Enouf, Kristin Tolksdorf, Simona Puzelli, Ana Carmen Ibáñez Pérez, Margaret Fitzgerald, Shirley Masse, Djin-Ye Oh, Marlena Kaczmarek, Sabrina Bacci, Esther Kissling, VEBIS Primary Care Vaccine Effectiveness Group, Sanja Kurečić Filipović, Vesna Višekruna Vučina , Ivana Ferenčak, Bernard Kaić, Katica Čusek Adamić, Mirjana Lana Kosanović Ličina, Ivana Mihin Huskić, Diana Nonković, Morana Tomljenović, Caroline Guerrisi, Cécile Souty, Thierry Blanchon, Titouan Launay, Alessandra Falchi, Marie Chazelle, Leïla Renard, Marie-Anne Rameix-Welti, Danielle Perez-Bercoff, Antonin Bal, Bruno Lina, Ralf Dürrwald, Barbara Biere, Janine Reiche, Marianne Wedde, Ute Preuß, Irmgard Stroetmann, Beatrix Oroszi, Viktória Velkey, Katalin Krisztalovics, Katalin Kristóf, Michael Joyce, Sara  Piacentini, Emanuela Giombini, Marzia Facchini, Angela Di Martino, Massimo Fabiani, Benedetta Bellini, Patrizio Pezzotti, Paola Stefanelli, Dirk Eggink, Anne Huiberts, Rianne van Gageldonk-Lafeber, Mariëtte Hooiveld, Ausenda Machado, Raquel Guiomar, João Almeida Santos, Licínia Gomes, Maria Elena Mihai, Alina Ivanciuc, Catalina Pascu, Sorin Dinu, Mihaela Oprea, Olivia Timnea, Adrian Jidovu, Susana Monge, Marcos Lozano, Francisco Pozo, Inmaculada Casas, Sonia Vázquez-Morón, Carmen Roman-Ortiz, Ignacio Campo-Palacio, Camino Trobajo-Sanmartín, Aitziber Echeverría, Itziar Casado, Guillermo Ezpeleta, Jesús Castilla, Ana Navascués, María Eugenia Portillo

  • June 15, 2026

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