Food Is Medicine: Evidence, Gaps, and Key Directions for the Future - Report - MDSpire

Food Is Medicine: Evidence, Gaps, and Key Directions for the Future

  • By

  • Rebekah J. Walker

  • Jennifer A. Campbell

  • Leonard E. Egede

  • June 24, 2026

  • 0 min

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Nutrition as Therapeutic Intervention: Current Evidence and Gaps

Background

Food insecurity affects millions and is linked to various social determinants of health, including poverty and access to healthcare. FIM and FAM interventions aim to integrate food-based medical treatments into healthcare systems to combat diet-related conditions. However, the evidence supporting their effectiveness on health outcomes is still inconclusive, as highlighted in various studies.

Data Highlights

No numerical data available.

Key Findings

  • Food insecurity is a complex issue influenced by structural factors beyond food availability.
  • FIM and FAM interventions have gained support but show limited evidence of improving clinical outcomes, as noted in recent reviews.
  • A study found that a produce prescription program reduced food insecurity and increased fruit and vegetable intake but did not show significant differences in health outcomes compared to a control group.
  • Limitations in existing studies include small sample sizes and lack of randomization.
  • Future research should focus on a variety of outcomes and consider contextual factors affecting food insecurity.

Clinical Implications

Healthcare providers should be aware of the multifaceted nature of food insecurity. However, the current evidence base necessitates cautious interpretation of the effectiveness of these interventions on health outcomes.

Conclusion

Further research is needed to establish the efficacy of FIM and FAM interventions in improving clinical outcomes and addressing the broader context of food insecurity.

Related Resources & Content

  1. Zimmer et al., JGIM, 2023 -- Nutrition as Therapeutic Intervention: Current Evidence, Existing Gaps, and Future Research Directions
  2. Journal of Gastroenterology — Nutritional Approaches and Gastrointestinal Wellness in Autism Spectrum Disorder
  3. Intensive Care Medicine — Research Priorities in Nutrition and Metabolism for Intensive Care Medicine
  4. The ASCO Post — Building and Sharing Dietary Evidence in Cancer Care Guest Editor
  5. Frontiers in Oncology — Editorial: Integrating nutrition in cancer therapy: approaches to improve patient outcomes and survival
  6. Food Security in the U.S. - Key Statistics & Graphics
  7. Current Dietary Guidelines
  8. Improving Care and Promoting Health in Populations: Standards of Care in Diabetes—2026
  9. Final Recommendation Statement: Screening for Food Insecurity
  10. GLIM consensus approach to diagnosis of malnutrition: A 5-year update - PubMed
  11. A Systematic Review of "Food Is Medicine" Randomized Controlled Trials for Noncommunicable Disease in the United States - Professional Heart Daily | American Heart Association
  12. Scholars@Duke publication: Produce Prescription Subsidy for Patients With Diabetes: A Pragmatic Randomized Clinical Trial.
  13. The nutritional impact of 7 versus 21 home-delivered medically tailored meals in patients with heart failure and malnutrition risk: a random order crossover feeding trial (MEDIMEALS) - PubMed

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