Neighborhood Socioeconomic Status and Short-Term Functional Outcomes in Systemic Lupus Erythematosus - Report - MDSpire
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Impact of Community Socioeconomic Factors on Short-Term Functional Outcomes in Patients with Systemic Lupus Erythematosus

  • By

  • Baljeet Rai

  • Jessica Fitzpatrick

  • Jing Li

  • Eric Roberts

  • Patricia Katz

  • Laura Plantinga

  • Gabriela Schmajuk

  • Jinoos Yazdany

  • May 20, 2026

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Impact of Community Socioeconomic Factors on Short-Term Functional Outcomes in Patients with Systemic Lupus Erythematosus

Overview

This study examines the relationship between neighborhood socioeconomic factors and functional outcomes in patients with systemic lupus erythematosus (SLE).

Background

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that significantly affects health-related quality of life (HRQoL), particularly in young women. Socioeconomic status (SES) is a critical social determinant of health that influences health outcomes in SLE. Understanding the impact of neighborhood SES on functional status is essential for addressing health disparities in SLE populations.

Data Highlights

In a national sample of over 20,000 adults with SLE, the study found that nearly one in five patients living in the most deprived neighborhoods experienced clinically significant functional status decline within a median follow-up of less than two years.

Key Findings

  • Greater neighborhood deprivation is associated with worse physical function in SLE patients.
  • One in five patients in socioeconomically deprived neighborhoods experienced significant functional decline.
  • Findings remained significant after adjusting for age, race, medication use, and comorbidity.
  • Functional status is a key component of HRQoL and is influenced by social and structural factors.

Clinical Implications

Healthcare providers should incorporate assessments of neighborhood socioeconomic factors into the management of patients with SLE. Interventions aimed at improving physical function should address the social determinants of health that affect these patients.

Conclusion

The study examines the impact of neighborhood socioeconomic factors on functional outcomes in SLE.

Related Resources & Content

  1. Rai, Arthritis Care & Research, 2023 -- Neighborhood Socioeconomic Status and Short‐Term Functional Outcomes in Systemic Lupus Erythematosus
  2. Clinical Rheumatology — Impact of Clinical Manifestations on Life Quality and Satisfaction in Patients with Systemic Lupus Erythematosus
  3. Clinical Rheumatology — Factors Influencing and Protective Elements of Achieving Low Disease Activity in Systemic Lupus Erythematosus: Insights from a Prospective Study in a Chinese Population
  4. Frontiers in Pediatrics — Impact of high disease activity on damage accrual and disease outcomes in childhood-onset systemic lupus erythematosus
  5. Clinical Rheumatology — Factors Influencing Disease Activity Improvement in Initially Hospitalized Systemic Lupus Erythematosus Patients: A Retrospective Multicenter Study of a Chinese Population
  6. https://rheumatology.org/api/asset/bltec93920aad624e33
  7. EULAR recommendations for the management of systemic lupus erythematosus with kidney involvement: 2025 update
  8. 2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis
  9. 2024 American College of Rheumatology (ACR)
  10. Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis | New England Journal of Medicine
  11. Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial - PubMed
  12. Trial of Anifrolumab in Active Systemic Lupus Erythematosus | New England Journal of Medicine
  13. Neighborhood Socioeconomic Status and Short‐Term Functional Outcomes in Systemic Lupus Erythematosus - Rai - Arthritis Care & Research - Wiley Online Library
  14. Increased prevalence, ER visits, and hospitalizations in medicare systemic lupus erythematosus patients living in socially vulnerable counties: A cross-sectional study - PubMed
  15. Impact of rural residence on clinical outcomes in SLE: a systematic review

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