Atherogenic index of plasma and severe headaches or migraines risk in US adults: a population-based cross-sectional analysis from NHANES 1999–2004 - Report - MDSpire
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Atherogenic index of plasma and severe headaches or migraines risk in US adults: a population-based cross-sectional analysis from NHANES 1999–2004
Clinical Report: Association Between Plasma Atherogenic Index and Risk of Severe Headaches or Migraines
Overview
This study investigates the association between the atherogenic index of plasma (AIP) and the risk of severe headaches or migraines in US adults using NHANES data. Elevated AIP levels were linked to a higher risk of severe headaches or migraines, particularly among younger individuals and women.
Background
Migraine is a prevalent neurological disorder that significantly impacts quality of life and is a leading cause of disability among young adults. Understanding the metabolic factors contributing to migraine susceptibility, such as lipid profiles indicated by the atherogenic index of plasma (AIP), is crucial for developing targeted prevention strategies. This study aims to fill the knowledge gap regarding the relationship between AIP and severe headaches or migraines.
Data Highlights
Quartile
Odds Ratio (OR)
95% Confidence Interval (CI)
Q1
Reference
-
Q2
1.481
1.105–1.984
Q4
1.799
1.228–2.637
Key Findings
Severe headache or migraine patients were predominantly younger (<45 years: 57.6%) and female (57.6%).
Higher risks of severe headaches or migraines were observed in the second (Q2: 26.5%) and fourth quartiles (Q4: 27.2%) of AIP.
After full adjustment, Q2 and Q4 showed significantly elevated risks for severe headaches or migraines compared to Q1.
Subgroup analyses indicated higher risks among individuals aged <45 years, females, and those without diabetes or coronary heart disease.
AIP was identified as a highly influential feature associated with severe headaches or migraines in XGBoost modeling.
Clinical Implications
Clinicians should consider the atherogenic index of plasma as a potential biomarker for assessing the risk of severe headaches or migraines, particularly in younger and female patients. This association underscores the importance of monitoring lipid profiles in patients presenting with severe headache symptoms.
Conclusion
The findings suggest a significant association between elevated AIP and the risk of severe headaches or migraines, warranting further prospective studies to explore this relationship and its underlying mechanisms.
