Non-linear and context-dependent association of maternal BMI with cumulative live birth in Chinese women undergoing intrauterine insemination: a retrospective study of 3788 cycles - Report - MDSpire

Non-linear and context-dependent association of maternal BMI with cumulative live birth in Chinese women undergoing intrauterine insemination: a retrospective study of 3788 cycles

  • By

  • Zhou, Huan-Qun

  • Zhu, Jian-Fang

  • Wang, Ai-Ai

  • Yuan, Qi-Long

  • Wu, Aihua

  • Lu, Shan

  • Zhou, Wen

  • May 22, 2026

  • 0 min

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Clinical Report: Maternal BMI and Live Birth Rates in Chinese Women Undergoing IUI

Overview

This study investigates the complex relationship between maternal body mass index (BMI) and live birth rates in women undergoing intrauterine insemination (IUI). It highlights a non-linear association, suggesting optimal BMI thresholds for improved reproductive outcomes.

Background

Understanding the impact of maternal BMI on fertility outcomes is crucial for optimizing assisted reproductive technologies. This topic is particularly relevant given the rising rates of obesity and its implications for reproductive health. The findings may inform individualized preconception management strategies.

Data Highlights

MeasureValue
First Cycle Live Birth Odds RatioNot significant (P > 0.05)
Per-Cycle Pregnancy Odds RatioaOR 1.04, P = 0.004
Per-Cycle Live Birth Odds RatioaOR 1.03, P = 0.030
Optimal BMI for Live Birth Probability~21.2 kg/m²
Cumulative Success Non-Linear PatternPLRT = 0.027

Key Findings

  • Maternal BMI showed no significant association with clinical pregnancy or live birth in the first cycle.
  • Per-cycle analysis revealed a modest positive correlation between BMI and pregnancy/live birth rates.
  • Cumulative success rates exhibited a non-linear pattern, peaking at a BMI of approximately 21.2 kg/m².
  • Subgroup analyses indicated heterogeneities based on basal FSH levels and treatment protocols.
  • Higher spontaneous abortion rates were observed in the obesity group, suggesting potential risks associated with high BMI.

Clinical Implications

Suggest practical steps for clinicians to tailor preconception management based on BMI.

Conclusion

Specify areas for future research to address gaps in understanding BMI's impact on IUI outcomes.

Related Resources & Content

  1. Frontiers in Endocrinology, 2026 -- Effect of weight loss intervention on assisted reproductive outcomes in women with obesity and infertility
  2. American Journal of Epidemiology, 2023 -- Influence of Grandmaternal Prepregnancy BMI on Infant Birthweight
  3. Frontiers in Endocrinology, 2026 -- Association between in vitro fertilization and preeclampsia
  4. Frontiers in Reproductive Health, 2026 -- Association of gestational weight gain with adverse pregnancy outcomes
  5. NICE, 2026 -- Advice about factors that can affect fertility
  6. Effect of female body mass index on intrauterine insemination outcomes: a systematic review and meta-analysis
  7. ESHRE Guidelines for Unexplained Infertility
  8. Advice about factors that can affect fertility | Fertility problems: assessment and treatment | Guidance | NICE

Original Source(s)

Non-linear and context-dependent association of maternal BMI with cumulative live birth in Chinese women undergoing intrauterine insemination: a retrospective study of 3788 cycles

  • by Zhou, Huan-Qun , Zhu, Jian-Fang , Wang, Ai-Ai , Yuan, Qi-Long , Wu, Aihua , Lu, Shan , Zhou, Wen

  • May 22, 2026

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