Clinical Report: Identification of Succinylation-Related Genes in AMI
Overview
This study identifies ASGR2 and NPL as potential biomarkers for acute myocardial infarction (AMI) through multi-omics and single-cell analysis.
Background
Acute myocardial infarction (AMI) is a leading cause of mortality globally. Current methods, including ECG and high-sensitivity cardiac troponin, have limitations that may lead to misclassification.
Data Highlights
Gene
Expression Trend
Correlation with Monocytes
ASGR2
Elevated in AMI
Positive correlation
NPL
Elevated in AMI
Positive correlation
Key Findings
18 succinylation-annotated genes were identified as related to AMI.
ASGR2 and NPL were prioritized as candidate biomarkers based on ROC and differential expression analyses.
Classical monocytes were more abundant in non-plaque rupture (NPR) than plaque rupture (PR) samples.
ELISA results showed elevated plasma levels of ASGR2 and NPL in AMI patients compared to controls.
Exploratory pseudotime analysis indicated expression trends of ASGR2 and NPL along a developmental axis in monocytes.
Clinical Implications
Further validation of ASGR2 and NPL is necessary before clinical application.
Conclusion
ASGR2 and NPL were identified as candidate biomarkers associated with acute myocardial infarction.
Higher annual oral corticosteroid exposure was associated with greater odds of systemic adverse events, with avascular bone necrosis and pneumonia showing dose-dependent associations with cumulative dose and osteoporosis associated with longer annual exposure duration.
