Navigating the Diagnostic Pitfalls of Cystic and Solid Breast Masses: A Comparative Case Report of Metaplastic Carcinoma and Benign Lesions - Report - MDSpire

Navigating the Diagnostic Pitfalls of Cystic and Solid Breast Masses: A Comparative Case Report of Metaplastic Carcinoma and Benign Lesions

  • By

  • Chu, Wenjie

  • Dong, Mengting

  • Sheng, Jiayu

  • Jiang, Ke

  • April 27, 2026

  • 0 min

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Clinical Report: Diagnostic Challenges in Cystic and Solid Breast Masses

Overview

This report highlights the diagnostic challenges associated with cystic and solid masses (CSMs) in the breast, particularly focusing on metaplastic breast carcinoma (MBC). Two case studies illustrate the potential for misdiagnosis and the importance of thorough diagnostic evaluation.

Background

Cystic and solid masses in the breast present significant diagnostic challenges due to their complex internal structures and a notable malignancy rate. Metaplastic breast carcinoma, a rare and aggressive form of triple-negative breast cancer, often mimics benign conditions, leading to misinterpretation and delayed treatment. Understanding the diagnostic nuances is critical for timely and accurate management.

Data Highlights

No numerical data provided in the article.

Key Findings

  • Metaplastic breast carcinoma (MBC) can present as a cystic and solid mass, complicating diagnosis.
  • Initial misdiagnosis can occur, as seen in Case 1, where MBC was misidentified as plasma cell mastitis.
  • Supplemental imaging, such as breast MRI, can aid in the accurate diagnosis of CSMs.
  • Pathological evaluation remains the gold standard for confirming the diagnosis of breast masses.
  • Characteristics of cystic fluid can provide diagnostic clues in differentiating between malignant and benign conditions.

Clinical Implications

Healthcare professionals should maintain a high index of suspicion for malignancy in patients presenting with cystic and solid breast masses. Comprehensive diagnostic approaches, including imaging and histopathological evaluation, are essential to avoid misdiagnosis and ensure timely treatment.

Conclusion

The cases presented underscore the importance of integrating clinical history, imaging findings, and pathological analysis in the diagnosis of breast masses. Enhanced awareness of the characteristics of metaplastic breast carcinoma can improve diagnostic accuracy.

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