Artificial intelligence for prediction of clinical response and therapeutic value in interventional pain management: a scoping review - Report - MDSpire

Artificial intelligence for prediction of clinical response and therapeutic value in interventional pain management: a scoping review

  • By

  • Mariana González Garcés

  • Jerónimo Cárdenas Montoya

  • Valeria Concha Fernández

  • Mario Andrés Torres Torres

  • Erwin Hernando Hernández Rincón

  • July 2, 2026

  • 0 min

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Clinical Report: Utilizing Artificial Intelligence in Interventional Pain Management

Overview

This scoping review maps the application of artificial intelligence (AI) in predicting clinical outcomes and treatment efficacy in interventional pain management, based on 25 studies. It highlights the variability in clinical responses and the need for robust external validation of AI models in this field.

Background

Chronic pain is a prevalent health issue that significantly impacts quality of life and healthcare systems, as evidenced by recent studies. Interventional pain management has become essential for patients with pain unresponsive to conservative treatments, with various procedures being utilized. However, variability in treatment outcomes necessitates innovative approaches, such as AI, to improve decision-making and predict therapeutic value.

Data Highlights

The review included 25 studies focusing on predictive applications of AI in various interventional pain procedures, including epidural injections and spinal cord stimulation, with specific methodologies and outcomes detailed in the studies.

Key Findings

  • AI models were primarily used to explore clinical response patterns, durability of benefit, and procedural risks, as reported in the included studies.
  • Most studies were retrospective and relied on internal validation, with limited external validation.
  • Outcome domains included opioid use trajectories and functional recovery.
  • Methodological heterogeneity was noted across the included studies.
  • Further prospective studies with robust external validation are necessary for clinical implementation.

Clinical Implications

The findings indicate that while AI has potential in predicting outcomes in interventional pain management, the current evidence is limited by methodological issues.

Conclusion

AI has been applied across various interventional pain domains, but limitations in study design and validation hinder its clinical applicability. Further research is essential to enhance the reliability of AI in this field.

Related Resources & Content

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  2. Frontiers in Pain Research — Leveraging artificial intelligence to optimize neuromodulation in the treatment of patients with chronic pain
  3. Updates in Surgery — Current Trends and Future Directions in the Use of Artificial Intelligence for Pain Management: A Bibliometric and Visual Review
  4. DIGITAL HEALTH — Global trends and hotspots of artificial intelligence in pain management: A bibliometric analysis
  5. Frontiers in Anesthesiology — From data to delivery: a mini-review on the clinical applications and challenges of artificial intelligence in obstetric anesthesia and analgesia
  6. Leveraging artificial intelligence to optimize neuromodulation in the treatment of patients with chronic pain
  7. Current Trends and Future Directions in the Use of Artificial Intelligence for Pain Management: A Bibliometric and Visual Review
  8. Global trends and hotspots of artificial intelligence in pain management: A bibliometric analysis
  9. Multisociety multispecialty consensus recommendations on corticosteroid injections for facet joint and sacroiliac joint pain
  10. Spinal Cord Stimulation for Persistent Spinal Pain Syndrome Type II: A Systematic Review and Subgroup Meta-analysis of Randomized Controlled Trials | medRxiv
  11. Machine learning predicts spinal cord stimulation surgery outcomes and reveals novel neural markers for chronic pain | Scientific Reports

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