Clinical Report: Systematic Review of Coordinated Changes in Oral and Gut Microbiota

Overview

This systematic review synthesizes evidence on oral and gut microbiome alterations in systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS). It highlights recurrent opposing abundance patterns across anatomical sites.

Background

The human microbiome plays a crucial role in host physiology and immune regulation. Dysregulation of the microbiome is frequently observed in autoimmune diseases, including connective tissue disorders like SLE and pSS. Understanding the interplay between oral and gut microbiomes may provide insights into disease mechanisms.

Data Highlights

Key Findings

• Intestinal Shannon and Simpson α-diversity were frequently reduced in SLE and pSS.
• Oral microbiome diversity was preserved or increased in these conditions.
• Specific taxa showed opposing abundance patterns, notably Streptococcus and Actinomycetota in SLE.
• Pseudomonadota were increased in the gut of pSS patients while decreased in the oral cavity.
• Parallel enrichment of Veillonella and Veillonellaceae was observed across both oral and gut sites.

Clinical Implications

Further research is needed to explore the interactions between oral and gut microbiomes in SLE and pSS.

Conclusion

This review presents findings on oral and gut microbiome alterations in connective tissue diseases.

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